{"id":"W3213418960","doi":"10.3390/curroncol28060380","title":"ERCC1 19007 Polymorphism in Greek Patients with Advanced Urothelial Cancer Treated with Platinum-Based Chemotherapy: Effect of the Changing Treatment Paradigm: A Cohort Study by the Hellenic GU Cancer Group","year":2021,"lang":"en","type":"article","venue":"Current Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"ERCC1; Medicine; Internal medicine; Oncology; Chemotherapy; Genotyping; Pembrolizumab; Immunotherapy; Genotype; Gastroenterology; Cancer; Nucleotide excision repair; DNA repair; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000481638,0.0003588577,0.0005500113,0.0005966563,0.0003324984,0.0005006102,0.000284365,0.0004630726,0.0007284071],"category_scores_gemma":[0.001392783,0.0003449469,0.0005405582,0.0008857015,0.0003444361,0.0002882764,0.0003663618,0.0003478432,0.0001812321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003007689,"about_ca_system_score_gemma":0.0002023753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002820011,"about_ca_topic_score_gemma":0.001917588,"domain_scores_codex":[0.9995723,0.0001373381,0.00004695913,0.0001290553,0.00005401722,0.00006039214],"domain_scores_gemma":[0.9992981,0.0001567409,0.0002309132,0.0001369066,0.00006290699,0.0001144475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003912922,0.00004552994,0.9963033,0.00001189928,0.00009501887,0.0004691343,0.0002039082,0.00004238591,0.0008785873,0.00001280186,0.00005468462,0.001491495],"study_design_scores_gemma":[0.0000314292,0.0002359554,0.9980849,0.000004418939,0.0000534619,0.001037264,0.000163432,0.0001058196,0.0000764514,0.00001999294,0.0001815308,0.000005244688],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997498,0.0000894381,0.00002991485,0.000009324038,0.000001990248,0.000005321459,0.00004533173,9.692466e-7,0.00006796706],"genre_scores_gemma":[0.9996436,0.000083693,0.00004591302,0.00001991902,0.000005280885,0.000005895402,0.0001359454,0.000001697348,0.00005815252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002820011,"threshold_uncertainty_score":0.005607188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013878200825008,"score_gpt":0.328220724488921,"score_spread":0.3080819424806709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}