{"id":"W3213442916","doi":"10.1038/s41589-021-00924-1","title":"Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2","year":2021,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":263,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; Canadian Glycomics Network; Canada Research Chairs; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; European Commission; U.S. Department of Health and Human Services; National Institutes of Health; University of Alberta","keywords":"Glycan; Glycolipid; Sialic acid; Neuraminidase; Viral entry; Sialyltransferase; Biochemistry; N-Acetylneuraminic acid; Chemistry; Receptor; Ganglioside; Heparan sulfate; Biology; Glycoprotein; Virology; Virus; Enzyme; Viral replication; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009898435,0.0001510571,0.000252122,0.00002801267,0.00003003597,0.00000995742,0.0001295513,0.000867132,0.000009078988],"category_scores_gemma":[0.0003965381,0.0001403677,0.00009804341,0.0001003536,0.0001402766,0.000002816525,0.000185474,0.0002973433,0.000002128089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001127544,"about_ca_system_score_gemma":0.00005684044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003625556,"about_ca_topic_score_gemma":0.000005517452,"domain_scores_codex":[0.9990196,0.00005191277,0.0002010033,0.0003655029,0.00005968402,0.0003022774],"domain_scores_gemma":[0.9995906,0.00003073875,0.00009563527,0.0001597537,0.00007486527,0.00004846069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000586665,0.00003920602,0.00574231,0.00001697457,0.0000899361,0.000002566595,0.00002010644,7.413308e-8,0.9902573,0.0004378743,0.0006590087,0.002676003],"study_design_scores_gemma":[0.0007625365,0.0001031001,0.000156301,0.00001287017,0.00002334558,0.000006095845,0.00005773265,0.000004296274,0.9823906,0.0003663838,0.01596076,0.0001559414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925708,0.005468579,0.00001132453,0.0003086427,0.0002240012,0.00005122126,0.0000559438,0.00001100241,0.001298552],"genre_scores_gemma":[0.9975674,0.0003701836,0.0002574016,0.001017605,0.0002133617,0.000005849981,0.0005202117,0.00001410121,0.00003394246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01530175,"threshold_uncertainty_score":0.6688116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006520111052943725,"score_gpt":0.2655728518115171,"score_spread":0.2590527407585734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}