{"id":"W3213442916","doi":"10.1038/s41589-021-00924-1","title":"Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2","year":2021,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":263,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; Canadian Glycomics Network; Canada Research Chairs; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; European Commission; U.S. Department of Health and Human Services; National Institutes of Health; University of Alberta","keywords":"Glycan; Glycolipid; Sialic acid; Neuraminidase; Viral entry; Sialyltransferase; Biochemistry; N-Acetylneuraminic acid; Chemistry; Receptor; Ganglioside; Heparan sulfate; Biology; Glycoprotein; Virology; Virus; Enzyme; Viral replication; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002274752,0.0006670414,0.0002844244,0.0002313222,0.0004086383,0.0007866526,0.0003280766,0.0004666866,0.002652942],"category_scores_gemma":[0.0002929365,0.0002577075,0.0005373181,0.0001463651,0.0002576173,0.0007644005,0.0009266863,0.0008492735,0.0009955174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008544379,"about_ca_system_score_gemma":0.0003584702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002172271,"about_ca_topic_score_gemma":0.002082538,"domain_scores_codex":[0.9996865,0.00005514188,0.0000153015,0.00003560686,0.00006243146,0.0001451001],"domain_scores_gemma":[0.9998951,0.00002794102,0.0000110877,0.00001081814,0.00002056404,0.00003437453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003911728,0.00002961108,0.0004158946,0.00004208699,0.0000104321,0.00009724055,0.00004812022,0.0001263494,0.9970409,0.00062226,0.00007771332,0.001098182],"study_design_scores_gemma":[0.00003729521,0.0002720341,0.01109509,0.00001863924,0.00002459354,0.0002774574,0.0003189266,0.004146915,0.9802293,0.0002618043,0.003301313,0.00001670494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927921,0.001312489,0.001512393,0.0001162893,0.00005051422,0.00004114264,0.0002045775,0.0000183654,0.003952028],"genre_scores_gemma":[0.9918189,0.0008888092,0.001582796,0.0001464417,0.00001982775,0.00002156382,0.000662052,0.00002005118,0.004839546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002652942,"threshold_uncertainty_score":0.008874953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006520111052943725,"score_gpt":0.2655728518115171,"score_spread":0.2590527407585734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}