{"id":"W3213527506","doi":"10.1038/s41388-021-02082-z","title":"NR1D1 regulation by Ran GTPase via miR4472 identifies an essential vulnerability linked to aneuploidy in ovarian cancer","year":2021,"lang":"en","type":"article","venue":"Oncogene","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; Montreal Heart Institute","funders":"Fonds de Recherche du Québec - Santé; Mitacs; Canadian Institutes of Health Research; Ovarian Cancer Canada","keywords":"Biology; Ran; Aneuploidy; Cancer; Ovarian cancer; Genetics; Carcinogenesis; GTPase; Vulnerability (computing); Cancer research; Gene; Cell biology; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008710414,0.0002123667,0.0001538018,0.0002288368,0.0001980847,0.000258541,0.0001078202,0.0002044547,0.00148577],"category_scores_gemma":[0.0001058294,0.0001033111,0.0001676117,0.0001146569,0.0001568899,0.0001421545,0.0002077561,0.0002957103,0.000264749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002739412,"about_ca_system_score_gemma":0.0001310995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003971393,"about_ca_topic_score_gemma":0.0008715961,"domain_scores_codex":[0.9999163,0.00001211533,0.0000072752,0.00002509677,0.00002491185,0.00001433341],"domain_scores_gemma":[0.9999503,0.000007800698,0.00001907097,0.000005801272,0.0000061693,0.00001085745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006591659,0.000007395523,0.0003179944,0.00002187582,0.000002289825,0.00004746725,0.000007288966,0.0000490214,0.9983653,0.0001091685,0.00002312771,0.0009831587],"study_design_scores_gemma":[0.00001039324,0.0001305358,0.01310544,0.000005689821,0.0000121406,0.0005618354,0.00004643425,0.001121797,0.9808931,0.0001136072,0.003993292,0.000005645871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921684,0.002425817,0.003224959,0.0001232921,0.00002623294,0.0000148075,0.0003703742,0.00008903956,0.001557091],"genre_scores_gemma":[0.9949908,0.0008746111,0.001781182,0.00003135831,0.000004513778,0.00002083943,0.0003890571,0.00001400092,0.00189366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00148577,"threshold_uncertainty_score":0.004970372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007673042920695377,"score_gpt":0.2725181608379629,"score_spread":0.2648451179172675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}