{"id":"W3213536910","doi":"10.1158/1538-7445.panca21-pr-010","title":"Abstract PR-010: Collateral amplification of the <i>KRAS</i> linked gene <i>PTHLH</i> governs pancreatic cancer growth and metastasis and reveals a new therapeutic vulnerability","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Bone health and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University","funders":"","keywords":"KRAS; Metastasis; Cancer research; Biology; Cancer; Medicine; Internal medicine; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001787315,0.000389495,0.0002752802,0.0002503402,0.0001479805,0.0004445515,0.0002205906,0.0003503252,0.003309008],"category_scores_gemma":[0.0001318951,0.0001571889,0.0003317264,0.0002027604,0.0004078646,0.0002122085,0.0002498213,0.0009538175,0.0008111193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002995061,"about_ca_system_score_gemma":0.0003084272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005051481,"about_ca_topic_score_gemma":0.0006767662,"domain_scores_codex":[0.9998239,0.00001687804,0.00001326987,0.00005235383,0.00005951302,0.00003428102],"domain_scores_gemma":[0.9998544,0.00001623056,0.00005969651,0.00001784858,0.00001132741,0.00004045806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004728247,0.0000523356,0.001439825,0.00004398223,0.00001213823,0.0001311607,0.00001103528,0.0001274295,0.9948369,0.000137644,0.0001518229,0.002582983],"study_design_scores_gemma":[0.0001894845,0.002866639,0.02342948,0.00001532859,0.0001080237,0.003571761,0.00007136276,0.002157453,0.9593547,0.000228797,0.007990307,0.00001660465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990171,0.0009463584,0.003385848,0.000249908,0.00003546586,0.00006657837,0.001787769,0.000273517,0.003083666],"genre_scores_gemma":[0.9916403,0.0005225449,0.001516784,0.0001192258,0.00001262158,0.00006027941,0.00190424,0.00007106803,0.004152813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003309008,"threshold_uncertainty_score":0.01106977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1201384021140007,"score_gpt":0.4232188595747039,"score_spread":0.3030804574607032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}