{"id":"W3213546933","doi":"10.1038/s41598-021-01363-7","title":"Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada","keywords":"Adjuvant; Antigen; Antibody; Virology; Immune system; Vaccination; Neutralizing antibody; Protein subunit; Immunology; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001690019,0.0003403301,0.0001850573,0.0001431483,0.00006862544,0.000145882,0.000116918,0.0002793153,0.0005225611],"category_scores_gemma":[0.0001190267,0.00008956507,0.0001544255,0.00007560453,0.0001346208,0.000215647,0.0001752792,0.0004159793,0.0001090233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001532345,"about_ca_system_score_gemma":0.000186944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002133319,"about_ca_topic_score_gemma":0.0004267384,"domain_scores_codex":[0.9998857,0.00002450722,0.000008131317,0.00001577333,0.00003913603,0.00002683305],"domain_scores_gemma":[0.9999632,0.000005109355,0.00001440688,0.000002568679,0.000006256256,0.000008539863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001174921,0.0001104953,0.0002229239,0.00004611756,0.000006744096,0.00003585455,0.00001057778,0.0003149806,0.9963486,0.00007218016,0.00004720991,0.002666971],"study_design_scores_gemma":[0.0000932463,0.006232563,0.003441893,0.00001690515,0.00004095752,0.0004123773,0.0000449567,0.003331868,0.9821939,0.00009522671,0.004087137,0.000008991974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961958,0.0007192339,0.002288147,0.00005650044,0.0000344002,0.00004933177,0.00006587616,0.00001855447,0.0005721846],"genre_scores_gemma":[0.9949787,0.0004850061,0.003419385,0.00005534209,0.00001326876,0.00003142355,0.0001832837,0.000005229503,0.0008282163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005225611,"threshold_uncertainty_score":0.001748145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03046259756066236,"score_gpt":0.3234514509234812,"score_spread":0.2929888533628188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}