{"id":"W3213549898","doi":"10.1182/blood-2021-145369","title":"High-Throughput Chemical Screen on Acute Myeloid Leukemia Stem Cells Identifies Novel Anti-LSC Compounds","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Université Laval; Hôpital de l'Enfant-Jésus; McGill University; McGill University Health Centre","funders":"","keywords":"Haematopoiesis; CD34; Leukemia; Stem cell; Bone marrow; Myeloid leukemia; Immunology; Cytotoxic T cell; Cord blood; Cancer research; Myeloid; Medicine; Biology; In vitro; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001669456,0.0005644899,0.0004601832,0.0008519637,0.0002242395,0.0003069803,0.0002671673,0.0002587235,0.002308389],"category_scores_gemma":[0.0001912527,0.0001230825,0.0002941803,0.0004706689,0.0001782499,0.0001354173,0.0002262691,0.0004856102,0.0008813894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002554434,"about_ca_system_score_gemma":0.000313424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000531421,"about_ca_topic_score_gemma":0.0015328,"domain_scores_codex":[0.9998314,0.00002445406,0.00001338771,0.00003151262,0.00007539065,0.00002375276],"domain_scores_gemma":[0.9998879,0.00002802029,0.00001432403,0.00001238673,0.00003297953,0.000024349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007282554,0.0001153646,0.0002937583,0.0001071844,0.00001212851,0.00007813346,0.00001317519,0.0005599404,0.9925096,0.00008951333,0.0003110275,0.00583718],"study_design_scores_gemma":[0.00003944046,0.001225716,0.002337378,0.00001627627,0.00004491729,0.0002018191,0.00001949702,0.001028266,0.9887816,0.00006977258,0.006224497,0.00001079047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686704,0.003383389,0.01217896,0.0004220346,0.00006811508,0.001008814,0.00646405,0.0005591307,0.007245093],"genre_scores_gemma":[0.96461,0.003717041,0.01718561,0.0003570236,0.00003127406,0.0004365358,0.007405607,0.00009572327,0.006161357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002308389,"threshold_uncertainty_score":0.007722378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02420899417155728,"score_gpt":0.2773976597964566,"score_spread":0.2531886656248993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}