{"id":"W3213562715","doi":"10.3389/fonc.2021.679173","title":"KIF15 Promotes Progression of Castration Resistant Prostate Cancer by Activating EGFR Signaling Pathway","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China; Shandong University","keywords":"Cancer research; Prostate cancer; PI3K/AKT/mTOR pathway; Protein kinase B; Signal transduction; Biology; Cell biology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839226,0.0001136202,0.0002137239,0.00003876909,0.00004435721,0.00000900332,0.00008837058,0.0002179826,0.000009183799],"category_scores_gemma":[0.00008930339,0.000112805,0.00004479524,0.0001190913,0.00006518771,0.000005762937,0.00006321166,0.00012252,2.020333e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009281694,"about_ca_system_score_gemma":0.000397962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004050917,"about_ca_topic_score_gemma":0.0001332141,"domain_scores_codex":[0.9989613,0.0001348148,0.0002930262,0.0003076722,0.0000828804,0.0002202903],"domain_scores_gemma":[0.9994939,0.00001123965,0.0001882241,0.0001551094,0.0001136947,0.00003782435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000181593,0.0001414554,0.01103025,0.000054965,0.0000332924,0.00001381226,0.0002399622,0.0000647636,0.9436399,0.00001093718,0.002306833,0.04228223],"study_design_scores_gemma":[0.0006247254,0.0003526197,0.0002877826,0.00008313487,0.000008777853,0.000005951627,0.000565277,0.0001693704,0.975578,0.00006876916,0.02213115,0.0001244561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933986,0.003669073,0.001743948,0.0002317713,0.000343299,0.0002497826,0.00005102491,0.000006117841,0.0003063904],"genre_scores_gemma":[0.9794319,0.0005637117,0.01883711,0.000106176,0.0000875855,0.0000860151,0.0002934927,0.0000211649,0.0005728181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04215778,"threshold_uncertainty_score":0.4600053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007587581375253834,"score_gpt":0.2783408774138445,"score_spread":0.2707532960385907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}