{"id":"W3213571777","doi":"10.1182/blood-2021-147598","title":"Patient-Reported Outcomes in a Phase 3, Randomized, Open-Label Study Evaluating the Efficacy of Axicabtagene Ciloleucel (Axi-Cel) Versus Standard of Care Therapy in Patients with Relapsed/Refractory Large B-Cell Lymphoma (ZUMA-7)","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; McGill University Health Centre; Hôpital de l'Enfant-Jésus; Queen Elizabeth II Health Sciences Centre","funders":"","keywords":"Medicine; Quality of life (healthcare); Internal medicine; Refractory (planetary science); Randomization; Randomized controlled trial; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004317342,0.001564454,0.002130281,0.0004719169,0.000524066,0.001010806,0.00114485,0.001821023,0.003952992],"category_scores_gemma":[0.002314,0.0005599524,0.002637888,0.000504865,0.001223924,0.001087225,0.0006208234,0.003458577,0.0006449297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001062404,"about_ca_system_score_gemma":0.001306173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006961706,"about_ca_topic_score_gemma":0.001545296,"domain_scores_codex":[0.9979098,0.001418656,0.0000931363,0.0002348533,0.0001710489,0.0001723656],"domain_scores_gemma":[0.9973469,0.0006657585,0.0008704095,0.0001781551,0.0002149073,0.0007238307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.965764,0.01945552,0.002069691,0.0003224445,0.001302207,0.00002521112,0.00003939302,0.0003990995,0.002054017,0.00004647753,0.0005035009,0.008018381],"study_design_scores_gemma":[0.7893409,0.2009231,0.007144972,0.00002376864,0.0008284627,0.00004160977,0.00003109125,0.000657466,0.000524689,0.00008270878,0.0003848427,0.00001646555],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932318,0.001841834,0.0003041156,0.0002433586,0.0001612049,0.002249918,0.001143493,0.00003574737,0.0007885638],"genre_scores_gemma":[0.9905419,0.0008058644,0.001090047,0.0006845429,0.0002718847,0.004383801,0.001551011,0.00001292138,0.0006580991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004317342,"threshold_uncertainty_score":0.02283257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04728086257192918,"score_gpt":0.3732617414523252,"score_spread":0.3259808788803961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}