{"id":"W3213586012","doi":"10.1182/blood-2021-149588","title":"A Real-World Canadian Experience of Asciminib Use in Chronic Myeloid Leukemia (CML) Patients Who Failed Multiple Lines of Tyrosine Kinase Inhibitor (TKI) Therapy","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Juravinski Cancer Centre; McGill University; University of Calgary; Brampton Civic Hospital; Alberta Health Services; Hôpital Maisonneuve-Rosemont; Western University; Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"","keywords":"Bosutinib; Dasatinib; Medicine; Nilotinib; Discontinuation; Internal medicine; Imatinib mesylate; Imatinib; Adverse effect; Oncology; Myeloid leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00080832,0.0002918602,0.0003784587,0.0006472428,0.003590892,0.001317503,0.0007246449,0.0005425184,0.001908546],"category_scores_gemma":[0.002603978,0.0002099329,0.0002858494,0.002325277,0.0008201059,0.0003530833,0.001037533,0.0008552933,0.000195723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02325757,"about_ca_system_score_gemma":0.02160739,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8728608,"about_ca_topic_score_gemma":0.9262873,"domain_scores_codex":[0.9988187,0.0001275519,0.00006487799,0.0001286727,0.0004891985,0.0003708698],"domain_scores_gemma":[0.9963838,0.0002827612,0.0008270838,0.00005703771,0.001052418,0.00139692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005722657,0.0003012625,0.9614505,0.0001400653,0.00007962034,0.003283159,0.003508857,0.0004563501,0.0009352554,0.0002860015,0.00473651,0.02425006],"study_design_scores_gemma":[0.00009260194,0.0007160635,0.9688568,0.0001052063,0.0001031135,0.004631486,0.007611372,0.001132707,0.0004291093,0.00009098094,0.01615634,0.00007421181],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934749,0.0006639484,0.0001287954,0.001183948,0.00001505589,0.00007173974,0.0008735172,0.00001181915,0.003576216],"genre_scores_gemma":[0.9977514,0.0005633333,0.0002169311,0.0004337164,0.00001840676,0.00001566766,0.0005123953,0.000007014338,0.0004810837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1271392,"threshold_uncertainty_score":0.2557757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.023282543078454,"score_gpt":0.2662995565006919,"score_spread":0.2430170134222379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}