{"id":"W3213612154","doi":"10.1182/blood-2021-147465","title":"Prognostic Impact of <i>NPM1</i> and <i>FLT3</i> Mutations at Diagnosis and Presence of Measurable Residual Disease (MRD) after Intensive Chemotherapy (IC) for Patients with Acute Myeloid Leukemia (AML) in Remission: Outcomes from the QUAZAR AML-001 Trial of Oral Azacitidine (Oral-AZA) Maintenance","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"NPM1; Myeloid leukemia; Medicine; Chemotherapy regimen; Cytarabine; Internal medicine; Oncology; Chemotherapy; Minimal residual disease; Leukemia; Disease; Residual; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001184761,0.000335214,0.0004708917,0.0002276918,0.0001866832,0.0006596549,0.000428504,0.0006862479,0.001815303],"category_scores_gemma":[0.001522991,0.0001252505,0.0007326761,0.0002532095,0.0003989812,0.0005025457,0.0004022606,0.001024137,0.0002247586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004532028,"about_ca_system_score_gemma":0.0003470822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009405835,"about_ca_topic_score_gemma":0.001752158,"domain_scores_codex":[0.9997012,0.000122402,0.00002228874,0.00006362066,0.00004095118,0.00004946576],"domain_scores_gemma":[0.9984215,0.0004207939,0.0005118061,0.00008268021,0.00006089436,0.0005023071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2027344,0.0018204,0.7243689,0.0004342809,0.001767553,0.0001239184,0.000187243,0.001336694,0.006816416,0.0001884253,0.002817838,0.05740394],"study_design_scores_gemma":[0.01192729,0.0246157,0.9545022,0.0001142644,0.002826644,0.0003446928,0.0001542119,0.001509419,0.00154006,0.0003308833,0.002096899,0.00003780383],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970459,0.001483126,0.00004512956,0.0002459181,0.00002156581,0.00003714743,0.000546459,0.000004088986,0.0005707613],"genre_scores_gemma":[0.9979064,0.0003102239,0.00007001061,0.0001765073,0.00008974568,0.00003171583,0.001172691,0.000002476826,0.0002403277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001815303,"threshold_uncertainty_score":0.0062657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01993687099546896,"score_gpt":0.2851539905242769,"score_spread":0.2652171195288079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}