{"id":"W3213622546","doi":"10.5267/j.ccl.2021.8.004","title":"Synthesis of 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives as new anticancer agents","year":2021,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Synthesis of Organic Compounds","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Advanced Centre for Treatment, Research and Education in Cancer; Tata Memorial Centre; Department of Science and Technology, Ministry of Science and Technology, India","keywords":"Chemistry; HeLa; Cell culture; In vitro; Potency; Trifluoromethyl; Stereochemistry; Cancer cell; Selectivity; Cancer cell lines; Pharmacology; Cervical carcinoma; Combinatorial chemistry; Cancer; Biochemistry; Cervical cancer; Organic chemistry; Internal medicine; Alkyl","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001827459,0.0004139896,0.0008677572,0.00008117738,0.00007616802,0.00004033815,0.0003562653,0.000141802,0.004499291],"category_scores_gemma":[0.001936929,0.000445856,0.0003208844,0.0005758018,0.0002541465,0.0001276426,0.0002019149,0.0003916238,0.00008754042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002891103,"about_ca_system_score_gemma":0.0006937881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000182906,"about_ca_topic_score_gemma":4.930961e-7,"domain_scores_codex":[0.9972139,0.00006218674,0.0006412386,0.0007350344,0.0008223477,0.0005252667],"domain_scores_gemma":[0.997695,0.0003453222,0.0002970803,0.000993986,0.0001790748,0.0004895317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007224146,0.0004958041,0.004458723,0.0007767517,0.0004495452,0.00006328728,0.0002000477,0.000001341551,0.9664218,0.000007392158,0.007395423,0.01965765],"study_design_scores_gemma":[0.001206565,0.00001031483,0.01301247,0.001040337,0.0004347838,0.0001185112,0.0001412658,0.00001071502,0.9772168,0.00003247435,0.006392134,0.0003835639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834155,0.002754248,0.000379956,0.01145058,0.0003458848,0.000200222,0.00002710892,0.0001148521,0.001311666],"genre_scores_gemma":[0.9952349,0.0005927921,0.002577229,0.0004362755,0.0006776731,0.00002764799,0.00006950553,0.00007604524,0.0003079103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01927409,"threshold_uncertainty_score":0.9997993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03461642305499961,"score_gpt":0.2988293432638313,"score_spread":0.2642129202088316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}