{"id":"W3213641793","doi":"10.25251/skin.5.supp.62","title":"Tapinarof Cream 1% Once Daily for the Treatment of Moderate to Severe Atopic Dermatitis in Children and Adults: The Pivotal Phase 3 ADORING Clinical Program","year":2021,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"LEO Pharma; EMD Serono; Bausch Health; Glenmark Pharmaceuticals; Sanofi Genzyme; Incyte; Dermira; Regeneron Pharmaceuticals; Kiniksa Pharmaceuticals; Celgene; Sanofi; Amgen; Pfizer; Galderma; Ortho Dermatologics; Eli Lilly and Company; Bristol-Myers Squibb; GlaxoSmithKline","keywords":"Atopic dermatitis; Medicine; Dermatology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001305459,0.0007689705,0.001314742,0.0002788837,0.0004273843,0.0007377118,0.0007098997,0.001006788,0.00482251],"category_scores_gemma":[0.0006784455,0.0002949023,0.001046687,0.0002492976,0.0004575686,0.0004914848,0.0002461988,0.001960572,0.0007300026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005119157,"about_ca_system_score_gemma":0.001277339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001501751,"about_ca_topic_score_gemma":0.004833961,"domain_scores_codex":[0.9997503,0.0001143906,0.00001340459,0.00003092465,0.0000334016,0.00005767648],"domain_scores_gemma":[0.9996247,0.00008089418,0.000058963,0.0000229285,0.0000518363,0.0001606574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4162958,0.05685169,0.007359664,0.004153615,0.001802916,0.0004101623,0.000384031,0.001405995,0.04169409,0.001277746,0.03721482,0.4311494],"study_design_scores_gemma":[0.6812907,0.2604856,0.02206283,0.0005720567,0.00078939,0.0007164408,0.0001490021,0.0009699363,0.003514227,0.0004677842,0.02893758,0.00004460196],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9275148,0.03711933,0.00228498,0.003236896,0.0009863897,0.0106948,0.003860326,0.0002528711,0.01404973],"genre_scores_gemma":[0.9355171,0.03268513,0.007039148,0.004670638,0.0007475358,0.006080533,0.003758525,0.00008037755,0.009420967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00482251,"threshold_uncertainty_score":0.01613295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0176862136550827,"score_gpt":0.3443466066119262,"score_spread":0.3266603929568435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}