{"id":"W3213659569","doi":"10.1182/blood-2021-147769","title":"Results from a Global Randomized Phase 3 Study of Guadecitabine (G) Vs Treatment Choice (TC) in 302 Patients with Relapsed or Refractory (r/r) Acute Myeloid Leukemia after Intensive Chemotherapy (ASTRAL-2 Study)","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Decitabine; Internal medicine; Medicine; Cytarabine; Clinical endpoint; Anthracycline; Chemotherapy regimen; Chemotherapy; Surrogate endpoint; Gastroenterology; Oncology; Azacitidine; Refractory (planetary science); Randomized controlled trial; Biology; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004051784,0.001890522,0.002985902,0.0004105598,0.0003884525,0.0009136804,0.0008205813,0.001506053,0.005627668],"category_scores_gemma":[0.002060955,0.0006163462,0.002827547,0.0005130776,0.001789489,0.0009435051,0.0005598518,0.003061073,0.0007403056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009450327,"about_ca_system_score_gemma":0.001425339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006969871,"about_ca_topic_score_gemma":0.002109372,"domain_scores_codex":[0.9982255,0.001304549,0.00006211116,0.0002055124,0.00005848826,0.0001438082],"domain_scores_gemma":[0.9981503,0.0006199807,0.0003453529,0.0001577702,0.00007768058,0.0006488732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9747274,0.007650679,0.00130263,0.0002344675,0.0009343644,0.00003353982,0.00004828522,0.0004827049,0.003163195,0.00005675917,0.0007477371,0.01061831],"study_design_scores_gemma":[0.8887904,0.105314,0.003664101,0.00001731011,0.000741097,0.0000332601,0.00002312751,0.0003137962,0.0004197241,0.0001570777,0.0005112208,0.00001484219],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913346,0.002224731,0.0005476499,0.0006777833,0.0001525559,0.002548498,0.001275848,0.00007583918,0.001162553],"genre_scores_gemma":[0.9879838,0.001362127,0.001711135,0.001552042,0.0002405711,0.003638987,0.002230118,0.00005452767,0.001226617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005627668,"threshold_uncertainty_score":0.02142817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01618916686023299,"score_gpt":0.3077389376887877,"score_spread":0.2915497708285548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}