{"id":"W3213660215","doi":"10.1182/blood-2021-148497","title":"Clinical Experience in the Randomized Phase 3 Sierra Trial: Anti-CD45 Iodine (131I) Apamistamab [Iomab-B] Conditioning Enables Hematopoietic Cell Transplantation with Successful Engraftment and Acceptable Safety in Patients with Active, Relapsed/Refractory AML Not Responding to Targeted Therapies","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ottawa Hospital; Princess Margaret Cancer Centre; University of Ottawa","funders":"","keywords":"Medicine; Internal medicine; Fludarabine; Tolerability; Transplantation; Oncology; Hematopoietic stem cell transplantation; Refractory (planetary science); Clinical trial; Adverse effect; Chemotherapy; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00733391,0.0009515238,0.001374878,0.0001862691,0.0004085462,0.00151276,0.000643493,0.001290817,0.004610301],"category_scores_gemma":[0.004282265,0.0003442843,0.001648829,0.0003661427,0.0007168725,0.0008987542,0.0005568617,0.00281215,0.001333635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005628933,"about_ca_system_score_gemma":0.001298212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007439836,"about_ca_topic_score_gemma":0.001394543,"domain_scores_codex":[0.9969113,0.00221956,0.0001454894,0.0003151374,0.0001765651,0.0002319232],"domain_scores_gemma":[0.9976005,0.000732972,0.0005121578,0.0003184692,0.000162996,0.0006728632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8082477,0.0121424,0.01127923,0.001123589,0.002094256,0.0004143418,0.0003608619,0.002311796,0.02162504,0.001263271,0.01850346,0.120634],"study_design_scores_gemma":[0.8186616,0.1436839,0.01754444,0.000111825,0.001418341,0.0005160242,0.00004950104,0.001312679,0.003074572,0.000651855,0.01291895,0.00005648744],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9501477,0.01076965,0.004853686,0.004103084,0.0007843066,0.008564333,0.005607625,0.0005083986,0.01466136],"genre_scores_gemma":[0.9636768,0.003062612,0.006824113,0.005054474,0.0006403197,0.007361788,0.007996988,0.000154605,0.005228233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00733391,"threshold_uncertainty_score":0.03878587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01908813488898635,"score_gpt":0.3181178042868145,"score_spread":0.2990296693978281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}