{"id":"W3213661800","doi":"10.1182/blood-2021-147780","title":"Glofitamab Plus R-CHOP Induces High Response Rates with Minimal Cytokine Release Syndrome (CRS) in Patients (pts) with Relapsed/Refractory (R/R) Non-Hodgkin Lymphoma (NHL) and Previously Untreated (1L) Diffuse Large B-Cell Lymphoma (DLBCL): Preliminary Results from a Dose-Escalation and Safety Run-in Phase Ib Study","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Cytokine release syndrome; Rituximab; CHOP; Obinutuzumab; Internal medicine; Vincristine; Prednisone; Lymphoma; Gastroenterology; Cyclophosphamide; Diffuse large B-cell lymphoma; Oncology; Chemotherapy; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008962127,0.0004863706,0.0008626443,0.0002386006,0.00015439,0.0005059842,0.000375069,0.0004855465,0.001487592],"category_scores_gemma":[0.0006706924,0.0002239419,0.0006311316,0.0002004113,0.0003307302,0.0004606762,0.000234277,0.00119376,0.0005110187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003506535,"about_ca_system_score_gemma":0.0002960497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000210673,"about_ca_topic_score_gemma":0.0006116885,"domain_scores_codex":[0.9996996,0.0001313455,0.00002691681,0.00005034466,0.00003549097,0.00005628353],"domain_scores_gemma":[0.9995496,0.00009368948,0.0001136068,0.00007587075,0.0000203775,0.0001469179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3322061,0.06152571,0.03133495,0.0006888814,0.001155081,0.0003955808,0.0005944817,0.003369772,0.1790257,0.0001471038,0.004660803,0.3848959],"study_design_scores_gemma":[0.1188193,0.7611609,0.08408907,0.00003568686,0.0007494912,0.001166001,0.0001262743,0.002430485,0.02758412,0.0001545692,0.003631884,0.00005221637],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981993,0.0005441758,0.0002524243,0.00006441029,0.00001643361,0.000198847,0.0002221086,0.00008868773,0.0004136785],"genre_scores_gemma":[0.9979644,0.000256343,0.0004894796,0.0001888746,0.00002765979,0.0001547846,0.0005335712,0.00001404789,0.0003708021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001487592,"threshold_uncertainty_score":0.004976451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007138151283826661,"score_gpt":0.2323652627059931,"score_spread":0.2252271114221664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}