{"id":"W3213674163","doi":"10.1182/blood-2021-147731","title":"Assessment of the Clonal Dynamics of Acquired Mutations in Patients (Pts) with Relapsed/Refractory Chronic Lymphocytic Leukemia (R/R CLL) Treated in the Randomized Phase 3 Murano Trial Supports Venetoclax-Rituximab (VenR) Fixed-Duration Combination Treatment (Tx)","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Venetoclax; Medicine; Bendamustine; Chronic lymphocytic leukemia; Internal medicine; Oncology; Ven; Minimal residual disease; Tumor lysis syndrome; Rituximab; KRAS; Lenalidomide; Leukemia; Gastroenterology; Lymphoma; Cancer; Multiple myeloma; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003296024,0.0001372512,0.0002530862,0.0002436918,0.0001538498,0.0003404785,0.0001777073,0.0002136605,0.001647272],"category_scores_gemma":[0.0005100581,0.0001230414,0.0001513883,0.0002060441,0.0001185107,0.0001725053,0.0002168091,0.0002884736,0.0001873451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002402451,"about_ca_system_score_gemma":0.0001347915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000514763,"about_ca_topic_score_gemma":0.0008330728,"domain_scores_codex":[0.9998704,0.00003464388,0.000009751329,0.00004876679,0.00001588181,0.00002049183],"domain_scores_gemma":[0.9997531,0.0000572582,0.00009242358,0.00002524119,0.00001668474,0.00005540813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.01620906,0.0005113814,0.8815309,0.00008331263,0.0001731542,0.0004852536,0.0001954876,0.0008620194,0.04914735,0.0001468049,0.001181662,0.04947357],"study_design_scores_gemma":[0.0006457225,0.005192615,0.9851021,0.00001329536,0.00009469287,0.001607258,0.00009569685,0.001990279,0.003358712,0.00009957144,0.001791277,0.000008777479],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993001,0.0001041357,0.00007100798,0.00001246215,0.000001538887,0.00001235107,0.0002580491,0.000005312045,0.000235013],"genre_scores_gemma":[0.9986115,0.00004571866,0.000190888,0.00003460039,0.000006065851,0.00002758336,0.0008363753,0.000002920392,0.000244388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001647272,"threshold_uncertainty_score":0.005510628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138376272924217,"score_gpt":0.2960673765236078,"score_spread":0.2846836137943656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}