{"id":"W3213683939","doi":"10.1016/j.ejmg.2021.104384","title":"Challenges and practical solutions for managing secondary genomic findings in primary care","year":2021,"lang":"en","type":"article","venue":"European Journal of Medical Genetics","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Sunnybrook Hospital; McMaster University; University Health Network; University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; University of Toronto; Ontario Ministry of Research and Innovation; Ontario Ministry of Research, Innovation and Science","keywords":"Medicine; Genomic information; Medical education; Nursing; Family medicine; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006838071,0.00008886781,0.0001384869,0.00004299034,0.00005133515,0.00002171395,0.0001255898,0.00005617749,0.00001092099],"category_scores_gemma":[0.0002233846,0.00008418201,0.00008010304,0.00002333506,0.00006656982,0.000002845482,0.0002448561,0.0001805534,0.000001168589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001691647,"about_ca_system_score_gemma":0.000479215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":1.388339e-7,"about_ca_topic_score_gemma":0.000007354683,"domain_scores_codex":[0.9989854,0.0001574087,0.0003002957,0.0001742201,0.0001838675,0.000198883],"domain_scores_gemma":[0.9994416,0.00003358987,0.00007864237,0.0001228227,0.000118924,0.0002044717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003779334,0.0004446116,0.001189971,0.0009144784,0.0003472298,0.006188915,0.002183633,0.0001653192,0.1060146,0.0008045073,0.004400109,0.8769687],"study_design_scores_gemma":[0.01144944,0.002561917,0.3232981,0.0007836843,0.0003481875,0.01056799,0.01028506,0.0003029765,0.007611052,0.0009226692,0.6308244,0.001044504],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8508506,0.1409831,0.00148557,0.003342729,0.0002568868,0.00007216295,0.00001533217,0.00000201144,0.00299162],"genre_scores_gemma":[0.9360386,0.05787814,0.00472361,0.0007383331,0.0005128859,0.000001046087,0.00004053847,0.00002881035,0.00003799387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8759242,"threshold_uncertainty_score":0.3432843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0283705567973329,"score_gpt":0.2723222428844215,"score_spread":0.2439516860870886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}