{"id":"W3213693309","doi":"10.5582/irdr.2021.01115","title":"Serum neurofilament light chain is not a useful biomarker of central nervous system involvement in women with Fabry disease","year":2021,"lang":"en","type":"article","venue":"Intractable & Rare Diseases Research","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Uniwersytet Łódzki","keywords":"Medicine; Montreal Cognitive Assessment; Biomarker; Neuropsychology; Internal medicine; Central nervous system; Fabry disease; Neurodegeneration; Disease; Neuropsychological assessment; Gastroenterology; Endocrinology; Cognitive impairment; Cognition; Psychiatry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008422919,0.0003930967,0.00077933,0.0007528099,0.0003738601,0.0005149149,0.0002912865,0.0006633135,0.001297027],"category_scores_gemma":[0.005206668,0.0003017627,0.0003528742,0.0006531046,0.0004704754,0.0003815421,0.0002909778,0.0004223394,0.000372597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002731632,"about_ca_system_score_gemma":0.0002303496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001996812,"about_ca_topic_score_gemma":0.001735633,"domain_scores_codex":[0.9995128,0.0001529439,0.00004716682,0.0001187683,0.00008753335,0.0000807504],"domain_scores_gemma":[0.9984192,0.0006796374,0.0004840692,0.000105872,0.0001110931,0.0002002096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003609599,0.00002120031,0.9965166,0.000008014411,0.0000279834,0.0004075842,0.00008275771,0.00002846796,0.0005749818,0.00001073605,0.00004808537,0.001912536],"study_design_scores_gemma":[0.00001966279,0.0003351281,0.9970917,0.00001087424,0.00006814068,0.001618374,0.0001491827,0.0002370925,0.0001778013,0.00004818654,0.0002390931,0.00000473338],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983268,0.000761274,0.0001210801,0.00008135766,0.0000131082,0.000006148896,0.00007968605,0.000004819572,0.0006056174],"genre_scores_gemma":[0.9996275,0.0001032532,0.00004820936,0.00004690362,0.00001545856,0.000003882398,0.00005268439,0.000001242514,0.0001007804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001996812,"threshold_uncertainty_score":0.004454494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03685014133396204,"score_gpt":0.3133766901272199,"score_spread":0.2765265487932579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}