{"id":"W3213709423","doi":"10.1038/s41467-021-26764-0","title":"Generation of functional ciliated cholangiocytes from human pluripotent stem cells","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children; Stem Cell Network; University Health Network","funders":"Hospital for Sick Children; University of Toronto; Japan Society for the Promotion of Science; Canada First Research Excellence Fund; Ministry of Education, Culture, Sports, Science and Technology; Government of Canada; Sick Kids Foundation; Genome Canada; Ontario Genomics; Ontario Genomics Institute; Cystic Fibrosis Canada","keywords":"Induced pluripotent stem cell; Stem cell; Cell biology; Biology; Human Induced Pluripotent Stem Cells; Computational biology; Embryonic stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004984772,0.0002430676,0.0001862984,0.0002819609,0.0002052878,0.0003556111,0.0002536115,0.0003979233,0.002979724],"category_scores_gemma":[0.0002933208,0.0002285446,0.000304449,0.0002578372,0.0002499972,0.0001710197,0.0003397681,0.0006051934,0.001155013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001542601,"about_ca_system_score_gemma":0.0003022107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002740758,"about_ca_topic_score_gemma":0.0005485527,"domain_scores_codex":[0.9997128,0.00004398934,0.0000579956,0.00003730509,0.0001116231,0.00003625131],"domain_scores_gemma":[0.9998081,0.00003646139,0.00003166172,0.00004035308,0.00004821191,0.00003514989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006638419,0.00002189964,0.0002665269,0.0001050018,0.000008197294,0.0002371085,0.00005949732,0.000336631,0.9927421,0.001129121,0.0004118719,0.004615679],"study_design_scores_gemma":[0.00008511042,0.0003773113,0.002866114,0.00003993598,0.00003851308,0.0008377985,0.00006703669,0.003154517,0.9561251,0.0004945953,0.03589409,0.0000197205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7826343,0.003477608,0.1720022,0.0008981566,0.0006827454,0.002728753,0.01502298,0.001197294,0.021356],"genre_scores_gemma":[0.915445,0.002473686,0.05687659,0.0004118086,0.00006117673,0.001034291,0.01110482,0.0001768819,0.0124158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002979724,"threshold_uncertainty_score":0.009968162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04044658220838616,"score_gpt":0.2799524902614269,"score_spread":0.2395059080530408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}