{"id":"W3213746728","doi":"10.1182/blood-2021-147568","title":"Novel Agents May be Preferable to Chemotherapy for Large B-Cell Lymphoma Progressing after CD19-CAR-T: A Multicenter Observational Study","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stem Cell Network","funders":"","keywords":"Medicine; Interquartile range; Internal medicine; CAR T-cell therapy; Cumulative incidence; Population; Cohort; Oncology; Cytokine release syndrome; Minimal residual disease; Lymphoma; Cancer; Chimeric antigen receptor; Immunotherapy; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00128287,0.0002468064,0.0005412324,0.0002837097,0.0005160241,0.000842754,0.0003831343,0.0007847194,0.002702835],"category_scores_gemma":[0.003908408,0.0002103948,0.0007963835,0.000785392,0.0003028816,0.0005912684,0.0003331886,0.0011978,0.0003742945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005260933,"about_ca_system_score_gemma":0.000538092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001686089,"about_ca_topic_score_gemma":0.001648677,"domain_scores_codex":[0.9990484,0.0003937458,0.000107727,0.0002443746,0.00008234971,0.0001233347],"domain_scores_gemma":[0.9960025,0.0006678631,0.002499933,0.0001897575,0.0001618161,0.0004781272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01275697,0.0012858,0.9783878,0.0001390712,0.000755461,0.000145357,0.0001266616,0.000123182,0.0005489503,0.00008585222,0.0006736703,0.004971262],"study_design_scores_gemma":[0.002053587,0.009750005,0.9814348,0.0001111108,0.000907047,0.0006706349,0.0005063438,0.0007749129,0.0003357801,0.0001811723,0.003245798,0.00002876881],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976242,0.001237566,0.00009858076,0.0001200523,0.00001523312,0.00003903445,0.0004985509,0.000002535841,0.0003642646],"genre_scores_gemma":[0.9988415,0.0003127265,0.00007254005,0.0001247736,0.0000463156,0.00003742092,0.0004358364,0.000002589436,0.0001263769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002702835,"threshold_uncertainty_score":0.009041846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09814892694299518,"score_gpt":0.3666650623625426,"score_spread":0.2685161354195474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}