{"id":"W3213805960","doi":"10.1139/bcb-2021-0255","title":"Paeonol reduces IL-β production by inhibiting the activation of nucleotide oligomerization domain-like receptor protein-3 inflammasome and nuclear factor-κB in macrophages","year":2021,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Paeonol; Inflammasome; Chemistry; Caspase 1; Paeonia suffruticosa; p38 mitogen-activated protein kinases; Lipopolysaccharide; AIM2; MAPK/ERK pathway; Pyroptosis; Apoptosis; Cell biology; NF-κB; Inflammation; Pharmacology; Signal transduction; Biochemistry; Receptor; Biology; Immunology; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040452,0.0004982274,0.0003692848,0.0003014866,0.000145531,0.0001869014,0.0001684488,0.0002716416,0.0009019261],"category_scores_gemma":[0.0001161563,0.0001806813,0.0003620996,0.0001402617,0.0001903552,0.0002836942,0.000145378,0.0007805501,0.000219156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000145637,"about_ca_system_score_gemma":0.0002967502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005480069,"about_ca_topic_score_gemma":0.0007232595,"domain_scores_codex":[0.999903,0.00001967814,0.00001535297,0.00001221644,0.00001934341,0.0000304656],"domain_scores_gemma":[0.9999471,0.000004892274,0.0000149703,0.000004535059,0.000009595266,0.00001890415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001306085,0.0004558987,0.0001551651,0.0001925981,0.00002424336,0.0000888076,0.00002078846,0.00008040853,0.993379,0.00006127826,0.0001158881,0.004119821],"study_design_scores_gemma":[0.0007060969,0.007749978,0.01116161,0.00003465975,0.0001244638,0.000466747,0.00007603102,0.001690626,0.9722757,0.0001329699,0.005565197,0.00001585018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884875,0.007421023,0.001865174,0.0002780659,0.0001196036,0.00007949372,0.00027822,0.0001160952,0.001354684],"genre_scores_gemma":[0.9896517,0.005388871,0.001621143,0.0002397561,0.0000540184,0.0001261238,0.000498224,0.00001194209,0.002408189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009019261,"threshold_uncertainty_score":0.003017306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003803024112630414,"score_gpt":0.1949728150019122,"score_spread":0.1911697908892818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}