{"id":"W3213814923","doi":"10.21203/rs.3.rs-1032345/v1","title":"Soluble Amyloid-Beta Isoforms Predict Downstream Alzheimer’s Disease Pathology","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Instituto Serrapilheira; Alzheimer's Association","keywords":"Gene isoform; Amyloid (mycology); Amyloid beta; Disease; Downstream (manufacturing); Pathology; Medicine; Neuroscience; Chemistry; Biology; Biochemistry; Gene; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001027708,0.0006273261,0.0003612028,0.0006689305,0.000209969,0.001460046,0.000186306,0.000540484,0.016807],"category_scores_gemma":[0.004343512,0.0002372712,0.0002826637,0.000496771,0.0002383912,0.000536939,0.0002783747,0.0006406933,0.004671796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002140228,"about_ca_system_score_gemma":0.0002607852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00125563,"about_ca_topic_score_gemma":0.0009995707,"domain_scores_codex":[0.9998019,0.00005320785,0.00001333543,0.0000501461,0.00005584128,0.00002546791],"domain_scores_gemma":[0.9987307,0.0005696459,0.0001959414,0.0001433616,0.0002087232,0.00015156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009622213,0.0009517297,0.7034246,0.0002931099,0.0005804489,0.002253806,0.000714138,0.003663559,0.04376908,0.00794168,0.07048103,0.1563046],"study_design_scores_gemma":[0.0004085096,0.0004200666,0.8905222,0.00007375804,0.000436882,0.004873004,0.0007573676,0.01481424,0.0198044,0.04658251,0.02125774,0.00004936057],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9605697,0.001373345,0.006108002,0.001989199,0.000369565,0.00003683737,0.005182665,0.0003193238,0.02405146],"genre_scores_gemma":[0.9655502,0.0006154445,0.004971283,0.0002899855,0.0002862787,0.00002404845,0.004720544,0.0001771978,0.02336493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.016807,"threshold_uncertainty_score":0.056225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08076764174462969,"score_gpt":0.4001610061706368,"score_spread":0.3193933644260071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}