{"id":"W3213821887","doi":"10.7554/elife.72919","title":"Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes","year":2021,"lang":"en","type":"article","venue":"eLife","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; National Institutes of Health; National Institute of Mental Health; Vetenskapsrådet; H2020 European Research Council; University of Oxford; Canadian Institutes of Health Research; Wellcome; Imperial College London; Novo Nordisk; Wellcome Trust; Steno Diabetes Center Copenhagen; Knut och Alice Wallenbergs Stiftelse; Diabetesförbundet; Diabetes UK; University of Alberta; Diabetes Research and Wellness Foundation; Alberta Diabetes Foundation; Novo Nordisk Fonden; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Glucagon; Hypoglycemia; Vasopressin; Insulin; Receptor; Hormone; Pancreatic hormone; Hyperglucagonemia; Type 1 diabetes","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001255955,0.0002334099,0.0002698468,0.0001247393,0.00008233047,0.0002185609,0.0001367594,0.0001432636,0.001221662],"category_scores_gemma":[0.0001538959,0.00009466479,0.0001089794,0.00008557901,0.0001527172,0.0001483956,0.0001236307,0.0005181205,0.0002385151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001543769,"about_ca_system_score_gemma":0.00007206106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001676847,"about_ca_topic_score_gemma":0.0001691135,"domain_scores_codex":[0.9999332,0.00001322166,0.000006047916,0.00001788086,0.00001768569,0.00001198087],"domain_scores_gemma":[0.9999133,0.000009092662,0.0000237803,0.000006904133,0.000008733412,0.00003808876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001385974,0.00005217981,0.002200672,0.0001106989,0.00001306937,0.0002154129,0.00002367639,0.00004158784,0.9871996,0.00007236059,0.0001773964,0.008507417],"study_design_scores_gemma":[0.0003735005,0.003537844,0.4086077,0.00006101893,0.0001647697,0.005553928,0.0002214306,0.001621599,0.5590919,0.0008457485,0.01988613,0.0000345945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890122,0.007285045,0.001256419,0.0001183899,0.00007460957,0.00001089245,0.0002769706,0.00007709944,0.001888277],"genre_scores_gemma":[0.9951663,0.002379699,0.0007928838,0.00009311837,0.00004339965,0.00001944215,0.0002482125,0.00001905963,0.001237805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001221662,"threshold_uncertainty_score":0.004086852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01310962440914075,"score_gpt":0.2531668916142579,"score_spread":0.2400572672051172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}