{"id":"W3213843812","doi":"10.3390/cells10113099","title":"Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; University of Guelph","funders":"Universidade de São Paulo; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Reprogramming; Biology; Induced pluripotent stem cell; Epigenetics; Endoderm; Germ cell; Germ layer; Cellular differentiation; Genetics; Cell biology; Embryonic stem cell; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002604729,0.0001922037,0.0002588587,0.0002866247,0.0002243015,0.0003416906,0.0001733868,0.0003026024,0.002200018],"category_scores_gemma":[0.0003217839,0.000112719,0.0003191324,0.0001703782,0.0001855743,0.00009207568,0.0002392969,0.0004598136,0.0004543349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001349983,"about_ca_system_score_gemma":0.0002896249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005613278,"about_ca_topic_score_gemma":0.0007458922,"domain_scores_codex":[0.9998759,0.00001484043,0.00002331496,0.00002987665,0.00003709715,0.00001889254],"domain_scores_gemma":[0.9999011,0.00002655625,0.00001215463,0.0000199168,0.00001276073,0.00002751566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002542521,0.00006698316,0.00663159,0.0001545138,0.00003974723,0.00301771,0.0003766684,0.0006804397,0.9721664,0.0008430566,0.0004300187,0.01533859],"study_design_scores_gemma":[0.0001744067,0.0009691529,0.04406625,0.0001025177,0.0002520113,0.01663142,0.0005472903,0.003731708,0.9027554,0.0006544182,0.03007984,0.00003550302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814668,0.000933011,0.01040799,0.0001066873,0.00008847688,0.0002608374,0.002155533,0.0001358551,0.004444752],"genre_scores_gemma":[0.9848191,0.001040336,0.006566862,0.0001049386,0.00001736943,0.0001813537,0.004190528,0.0000541956,0.003025285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002200018,"threshold_uncertainty_score":0.007359743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796104578116742,"score_gpt":0.2355499426806126,"score_spread":0.2175888968994451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}