{"id":"W3213843812","doi":"10.3390/cells10113099","title":"Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; University of Guelph","funders":"Universidade de São Paulo; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Reprogramming; Biology; Induced pluripotent stem cell; Epigenetics; Endoderm; Germ cell; Germ layer; Cellular differentiation; Genetics; Cell biology; Embryonic stem cell; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009154293,0.0002195796,0.0002754296,0.00003970938,0.00006344957,0.00004186048,0.0002794333,0.0002728602,0.000375217],"category_scores_gemma":[0.00002490945,0.0002251442,0.0001631962,0.0001060661,0.0000728915,0.000007867431,0.0002996597,0.00013981,0.0001432326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002986231,"about_ca_system_score_gemma":0.000181238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001418767,"about_ca_topic_score_gemma":0.00004775604,"domain_scores_codex":[0.9981026,0.0001958201,0.0003702593,0.0006208026,0.0003799453,0.0003305434],"domain_scores_gemma":[0.9987575,0.00003692207,0.000163507,0.0006461981,0.0002456776,0.0001502425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003705942,0.0002562866,0.001440086,0.00002074992,0.00006968049,0.00003560933,0.00005987628,0.000166149,0.9930734,2.935829e-7,0.004385568,0.0004552429],"study_design_scores_gemma":[0.0009930241,0.0001151801,0.005082733,0.0000126494,0.00003520064,0.000001120684,0.00002413387,0.0001937625,0.9856322,0.000009457866,0.007664538,0.0002360139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996502,0.0007954795,0.0004957507,0.00002217526,0.0008637403,0.0002315303,0.0004583634,0.000009303672,0.0006216413],"genre_scores_gemma":[0.9926009,0.0003573879,0.001544868,0.0001547416,0.0002870861,0.00001278772,0.003160018,0.00004212099,0.001840155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007441211,"threshold_uncertainty_score":0.9181113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796104578116742,"score_gpt":0.2355499426806126,"score_spread":0.2175888968994451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}