{"id":"W3213855053","doi":"10.1182/blood-2021-153613","title":"An Open-Label, First-in-Human, Phase I Trial of Daily Pclx-001","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Spinal Cord Injury BC; University of Alberta","funders":"","keywords":"Tolerability; Medicine; Pharmacokinetics; In vivo; Lymphoma; Cancer; Internal medicine; Oncology; Pharmacology; Cancer research; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001015032,0.001759704,0.001166236,0.0003951358,0.0005185839,0.001288032,0.0009877228,0.001452327,0.005832532],"category_scores_gemma":[0.0007043043,0.000476818,0.0006187058,0.0003326499,0.001297157,0.001456224,0.0004357545,0.003660917,0.001150252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001139991,"about_ca_system_score_gemma":0.001451573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006991643,"about_ca_topic_score_gemma":0.001292071,"domain_scores_codex":[0.9997274,0.00007662112,0.00001235558,0.00007727945,0.00002927256,0.00007697392],"domain_scores_gemma":[0.9993473,0.00008653331,0.000112903,0.00006661036,0.00003789438,0.0003487951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.496725,0.1780946,0.005135315,0.001143183,0.0008513301,0.0005709667,0.0006175892,0.004120398,0.1331943,0.001053234,0.01283782,0.1656564],"study_design_scores_gemma":[0.3532141,0.6140518,0.008280386,0.00003585039,0.0002123657,0.0006223019,0.0001128932,0.002463301,0.01219408,0.0006197563,0.008151812,0.00004136962],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877048,0.001290916,0.001417923,0.0006637769,0.000161267,0.003431344,0.001787089,0.0003600197,0.00318291],"genre_scores_gemma":[0.9835325,0.0009836538,0.002277998,0.001147534,0.0001633684,0.002547069,0.003036522,0.00008339318,0.006227948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005832532,"threshold_uncertainty_score":0.01951176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0352055203736284,"score_gpt":0.3235876323081149,"score_spread":0.2883821119344865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}