{"id":"W3213899450","doi":"10.1101/2021.11.12.468446","title":"Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Glycogen Storage Diseases and Myoclonus","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ontario Ministry of Economic Development and Innovation; Medical Research Council; European Federation of Pharmaceutical Industries and Associations; Novartis Pharma; Wellcome Trust; Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Diamond Light Source; Genome Canada; Pfizer","keywords":"Allosteric regulation; Glycogen synthase; Phosphorylation; Glycogen; Biochemistry; Glycogen branching enzyme; Chemistry; GSK-3; Enzyme activator; Glucose 6-phosphate; Glycogen debranching enzyme; Protein subunit; Cell biology; Enzyme; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003944395,0.0004187871,0.0006237804,0.000107815,0.0001950967,0.000106864,0.0001912172,0.0003714709,0.00005868932],"category_scores_gemma":[0.0003139219,0.0003800335,0.0002965184,0.0002671478,0.0001494525,0.00008374316,0.0002026782,0.0002810689,0.00000179019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001448595,"about_ca_system_score_gemma":0.0003700542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001616754,"about_ca_topic_score_gemma":0.000001529204,"domain_scores_codex":[0.9978884,0.0000654887,0.0005445023,0.000761679,0.0004019762,0.0003378885],"domain_scores_gemma":[0.9972933,0.0001102808,0.0004767326,0.001088348,0.0007820831,0.0002492332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001910662,0.0001755878,0.001098196,0.0009074214,0.0004627302,0.00008739738,0.00001580476,0.00003943301,0.9963034,0.0004232878,0.0002678907,0.00002778414],"study_design_scores_gemma":[0.001130542,0.0001297101,0.03296152,0.0006257998,0.001482306,1.387417e-7,0.00001549711,0.001130661,0.9606254,0.00000329022,0.001494182,0.0004010165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631803,0.03026193,0.003757175,0.0002540647,0.0003264069,0.001652159,0.0004701605,0.00009450391,0.000003301445],"genre_scores_gemma":[0.9969822,0.0007704207,0.001431624,0.0002158449,0.00013493,0.0003335952,0.00000958345,0.0001151384,0.000006717829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03567806,"threshold_uncertainty_score":0.9998652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120524811657303,"score_gpt":0.2353662290631263,"score_spread":0.2241609809465533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}