{"id":"W3213899689","doi":"10.1016/s2152-2650(21)02101-7","title":"OAB-027: Idecabtagene vicleucel (ide-cel, bb2121), a BCMA-directed CAR T-cell therapy, for the treatment of patients with relapsed and refractory multiple myeloma (RRMM): updated results from KarMMa","year":2021,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Lenalidomide; Pomalidomide; Fludarabine; Internal medicine; Bortezomib; Carfilzomib; Rituximab; Daratumumab; Regimen; Multiple myeloma; Refractory (planetary science); Clinical endpoint; Oncology; Cyclophosphamide; Gastroenterology; Surgery; Clinical trial; Chemotherapy; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008581199,0.0007418296,0.001660459,0.0001600432,0.0003269465,0.00008827494,0.0004368392,0.0006578644,0.0004542765],"category_scores_gemma":[0.001212281,0.0004920127,0.0006494287,0.0007307088,0.0007619006,0.0001496812,0.0001539318,0.0003895946,0.00004099839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001127131,"about_ca_system_score_gemma":0.002203118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008450315,"about_ca_topic_score_gemma":0.0002763866,"domain_scores_codex":[0.9937177,0.0006866826,0.002028777,0.001643114,0.001023318,0.0009004529],"domain_scores_gemma":[0.9888839,0.006294942,0.0007393107,0.002172441,0.001241709,0.0006677213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.07466687,0.004920714,0.07622638,0.00006924595,0.002062059,0.000350752,0.001207035,0.0000110813,0.0772812,0.000004765442,0.004443677,0.7587562],"study_design_scores_gemma":[0.07930446,0.006063672,0.7344058,0.0001340962,0.0004338982,0.00001487657,0.0002378735,0.00130252,0.06235294,0.00003681131,0.1152474,0.0004656463],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908775,0.003240532,0.00003400752,0.000614226,0.0004479277,0.002876493,0.001079072,0.0002215245,0.0006086825],"genre_scores_gemma":[0.9827449,0.005052194,0.002292508,0.0006732825,0.0005748494,0.0002690045,0.002379075,0.0002184735,0.005795741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7582906,"threshold_uncertainty_score":0.9997532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03591386775633376,"score_gpt":0.310774505472544,"score_spread":0.2748606377162102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}