{"id":"W3213918788","doi":"10.1002/hep4.1854","title":"Single‐Cell, Single‐Nucleus, and Spatial RNA Sequencing of the Human Liver Identifies Cholangiocyte and Mesenchymal Heterogeneity","year":2021,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Liver physiology and pathology","field":"Medicine","cited_by":281,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Amgen (Canada); University of Toronto; Canada Research Chairs; University Health Network","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Canada First Research Excellence Fund; National Human Genome Research Institute; University of Toronto; Chan Zuckerberg Initiative; Public Health Agency; Public Health Agency of Canada; PSC Partners Seeking a Cure; Silicon Valley Community Foundation","keywords":"Mesenchymal stem cell; Cholangiocyte; Cell; RNA; Cell biology; Nucleus; Biology; Computational biology; Genetics; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001742125,0.00009388913,0.0001577691,0.0002731088,0.0001585125,0.000268161,0.00007214893,0.0001531594,0.00054482],"category_scores_gemma":[0.0002550035,0.00009538098,0.0001455065,0.0001965408,0.0001754982,0.00008004479,0.0001604661,0.0001354311,0.0002902765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001026448,"about_ca_system_score_gemma":0.0001998145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001134039,"about_ca_topic_score_gemma":0.003225995,"domain_scores_codex":[0.9998643,0.00001767843,0.000008196653,0.00004818428,0.00004624001,0.00001528725],"domain_scores_gemma":[0.9998832,0.00003354795,0.0000198733,0.00001755458,0.0000339359,0.00001178708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004889195,0.000003864838,0.003878463,0.00004129297,0.000009238307,0.00004680548,0.00007599025,0.0001751339,0.9908316,0.00007765569,0.00007138678,0.004739695],"study_design_scores_gemma":[0.000010126,0.0001409459,0.2218684,0.00002791784,0.00007171443,0.001023314,0.0004525322,0.005919421,0.7625072,0.0005228242,0.007432709,0.00002287187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679481,0.00135603,0.02630687,0.0001011261,0.00001420143,0.0000283847,0.002358634,0.0001401164,0.001746531],"genre_scores_gemma":[0.9813426,0.0007891334,0.01442151,0.0001206772,0.00001029701,0.00004730415,0.002123203,0.00006986835,0.001075329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001134039,"threshold_uncertainty_score":0.002254903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.075352028894667,"score_gpt":0.2994515766740878,"score_spread":0.2240995477794208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}