{"id":"W3213918788","doi":"10.1002/hep4.1854","title":"Single‐Cell, Single‐Nucleus, and Spatial RNA Sequencing of the Human Liver Identifies Cholangiocyte and Mesenchymal Heterogeneity","year":2021,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Liver physiology and pathology","field":"Medicine","cited_by":281,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Amgen (Canada); University of Toronto; Canada Research Chairs; University Health Network","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Canada First Research Excellence Fund; National Human Genome Research Institute; University of Toronto; Chan Zuckerberg Initiative; Public Health Agency; Public Health Agency of Canada; PSC Partners Seeking a Cure; Silicon Valley Community Foundation","keywords":"Mesenchymal stem cell; Cholangiocyte; Cell; RNA; Cell biology; Nucleus; Biology; Computational biology; Genetics; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001300226,0.0001087436,0.0002891141,0.00004708827,0.0003880373,0.000009437003,0.0002239281,0.0001648305,0.00002814804],"category_scores_gemma":[0.00009700154,0.00009100997,0.00006850054,0.0001022035,0.001134006,0.00005516407,0.0007029495,0.0002998685,0.000003691744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003291569,"about_ca_system_score_gemma":0.00008488725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003332055,"about_ca_topic_score_gemma":0.001350542,"domain_scores_codex":[0.9988312,0.0004992806,0.000245867,0.0002073878,0.00006350672,0.0001528317],"domain_scores_gemma":[0.99836,0.0002280772,0.0001302272,0.0011013,0.0001288941,0.00005146175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001257761,0.0001719758,0.1705491,0.00005594149,0.00006902189,0.00002580133,0.001187144,2.556454e-7,0.8263059,0.001090235,0.00006874136,0.0004633329],"study_design_scores_gemma":[0.00112809,0.0002146291,0.5116112,0.00009372748,0.0004252758,0.001483782,0.0005028585,0.0003276154,0.4815836,0.001105972,0.00132909,0.0001941992],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924712,0.004374456,0.00003812897,0.001065702,0.00008025948,0.0001278383,0.00001592552,0.00002266682,0.001803859],"genre_scores_gemma":[0.9977933,0.0005908108,0.0009318891,0.0004853813,0.00002347751,0.000008518851,0.0000397213,0.00001026768,0.0001166891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3447223,"threshold_uncertainty_score":0.4178293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.075352028894667,"score_gpt":0.2994515766740878,"score_spread":0.2240995477794208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}