{"id":"W3213936100","doi":"10.3389/fped.2021.777108","title":"Minimal Residual Disease Prior to and After Haematopoietic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia: What Level of Negativity Is Relevant?","year":2021,"lang":"en","type":"review","venue":"Frontiers in Pediatrics","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Medicine; Transplantation; Negativity effect; Minimal residual disease; Haematopoiesis; Stem cell; Disease; Hematopoietic stem cell transplantation; Lymphoblastic Leukemia; Immunology; Oncology; Pediatrics; Internal medicine; Leukemia; Developmental psychology; Genetics; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00189153,0.0002721635,0.0008676081,0.0006979516,0.0003328155,0.001518452,0.0006334299,0.0008938747,0.001106075],"category_scores_gemma":[0.009095866,0.000237969,0.0004282091,0.000842625,0.0008839933,0.001271388,0.000527056,0.001279431,0.0003300605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006162232,"about_ca_system_score_gemma":0.0007224663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002364366,"about_ca_topic_score_gemma":0.004072228,"domain_scores_codex":[0.9986783,0.0005255168,0.0001968526,0.000175959,0.0002398338,0.0001834191],"domain_scores_gemma":[0.9961447,0.001797833,0.001117873,0.000084592,0.0004217323,0.0004332955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008281092,0.00005431546,0.9257135,0.0006476603,0.000132293,0.001049822,0.0003729579,0.0001947987,0.0004376025,0.0003432658,0.001466008,0.06875961],"study_design_scores_gemma":[0.0000398598,0.0006743825,0.9729469,0.001196047,0.0004949043,0.008961248,0.002796228,0.0006299163,0.0004748753,0.001008384,0.01072841,0.00004882886],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8324882,0.1568373,0.0006627543,0.005576304,0.0003263008,0.00004847106,0.0005255598,0.00002109288,0.003514051],"genre_scores_gemma":[0.9817287,0.01601717,0.0005025364,0.0007096442,0.0004243646,0.00002373014,0.0003590012,0.000009533363,0.00022533],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002364366,"threshold_uncertainty_score":0.01000345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01759341219752409,"score_gpt":0.2761812438640988,"score_spread":0.2585878316665747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}