{"id":"W3213936100","doi":"10.3389/fped.2021.777108","title":"Minimal Residual Disease Prior to and After Haematopoietic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia: What Level of Negativity Is Relevant?","year":2021,"lang":"en","type":"review","venue":"Frontiers in Pediatrics","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Medicine; Transplantation; Negativity effect; Minimal residual disease; Haematopoiesis; Stem cell; Disease; Hematopoietic stem cell transplantation; Lymphoblastic Leukemia; Immunology; Oncology; Pediatrics; Internal medicine; Leukemia; Developmental psychology; Genetics; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003167289,0.0005902169,0.00208936,0.001046735,0.0000377066,0.00008350416,0.0001991694,0.0004521933,0.000003806027],"category_scores_gemma":[0.00007542857,0.0004956509,0.0001338713,0.001139284,0.00019065,0.0002767913,0.0001741376,0.0006198356,0.000002825378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008001122,"about_ca_system_score_gemma":0.002790597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003951478,"about_ca_topic_score_gemma":0.00002169698,"domain_scores_codex":[0.9964354,0.0002656112,0.0008957072,0.000972708,0.0008572416,0.0005732992],"domain_scores_gemma":[0.9984258,0.0001939865,0.0002894925,0.0004567895,0.0001156291,0.0005182432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00535799,0.0007064075,0.4435814,0.1328456,0.0004191239,0.006635264,0.002968872,0.000006334332,7.483572e-7,0.000001431625,0.003298292,0.4041786],"study_design_scores_gemma":[0.03410405,0.001988503,0.7154258,0.2022791,0.03508578,0.003065603,0.001388015,0.000361472,0.00004876549,0.00003564386,0.002647767,0.003569532],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1785269,0.8173619,0.0010303,0.0000577085,0.0001480404,0.00211436,0.0007458632,0.00001211446,0.000002837557],"genre_scores_gemma":[0.01547657,0.9798944,0.003926673,0.00007113988,0.0001267367,0.0001473937,0.000149804,0.000100706,0.0001065789],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4006091,"threshold_uncertainty_score":0.9997495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01759341219752409,"score_gpt":0.2761812438640988,"score_spread":0.2585878316665747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}