{"id":"W3213956481","doi":"10.1085/jgp.2021ecc17","title":"Structural basis for diamide modulation of ryanodine receptor","year":2021,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Japan Society for the Promotion of Science; National Key Research and Development Program of China; Canadian Institutes of Health Research; Michael Smith Health Research BC; National Natural Science Foundation of China; Japan Agency for Medical Research and Development","keywords":"Ryanodine receptor; RYR1; Biology; In silico; Mutagenesis; Mutation; Biochemistry; Diamondback moth; Cell biology; Biophysics; Receptor; Chemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001427454,0.00007841545,0.000171105,0.00001876603,0.00004952308,0.000002955345,0.0001418482,0.0000732819,0.00002604318],"category_scores_gemma":[0.00008716704,0.00005277473,0.000132675,0.00005056477,0.00006485033,0.000002644169,0.00003802053,0.00005673667,4.865269e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008121358,"about_ca_system_score_gemma":0.0000892746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004040415,"about_ca_topic_score_gemma":0.00001422311,"domain_scores_codex":[0.9993602,0.0001048562,0.0002627765,0.00007927866,0.00007012096,0.0001227371],"domain_scores_gemma":[0.9991598,0.00002828827,0.0002453082,0.0001730154,0.0003684196,0.00002524287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004252607,0.00001332673,0.00007797853,0.00001415166,0.00007640437,2.385589e-7,0.00003938458,0.00465072,0.9917586,0.00007012624,0.002138813,0.0007349945],"study_design_scores_gemma":[0.0004024938,0.0004320073,0.01812013,0.000007352442,0.00003621011,0.0000236282,0.00004140595,0.0002267356,0.9766632,0.001064246,0.002915532,0.0000670322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974973,0.001103834,0.0007518759,0.0002348008,0.0003000112,0.00005166671,0.00002110732,7.862708e-7,0.00003867897],"genre_scores_gemma":[0.9955253,0.0004359039,0.002589574,0.0002084581,0.0008487576,0.000001213302,0.00004121536,0.000009548486,0.0003400487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01804215,"threshold_uncertainty_score":0.2152091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01075295532088574,"score_gpt":0.2539759545656444,"score_spread":0.2432229992447587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}