{"id":"W3213974098","doi":"10.1182/blood-2021-145723","title":"Analysis of Duration of Response, Exposure-Adjusted Safety and Progression to Acute Myeloid Leukemia (AML) for Patients with Lower-Risk Myelodysplastic Syndromes (LR-MDS) Receiving Luspatercept in the MEDALIST Study","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Myelodysplastic syndromes; Medicine; Myeloid leukemia; Internal medicine; Oncology; Leukemia; Cytarabine; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005789343,0.0006180645,0.001113849,0.0004296739,0.0001901426,0.0009229652,0.0008687654,0.0006611002,0.003139399],"category_scores_gemma":[0.004106139,0.0002532602,0.003770649,0.0005359928,0.0003157983,0.000649674,0.0005481442,0.001217657,0.0003238014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005221325,"about_ca_system_score_gemma":0.0005245331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004861187,"about_ca_topic_score_gemma":0.000801309,"domain_scores_codex":[0.9973895,0.001382971,0.0002516674,0.0004504035,0.0003910359,0.0001344473],"domain_scores_gemma":[0.993922,0.001914245,0.002451746,0.0007781494,0.0002911047,0.0006426946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.4328534,0.001355825,0.5043961,0.001152999,0.02411262,0.0002488283,0.0002025252,0.003146449,0.004805041,0.0003995088,0.003538565,0.02378812],"study_design_scores_gemma":[0.03781747,0.03319696,0.9051917,0.00008706321,0.01077965,0.0005668483,0.0001080387,0.004622433,0.002030077,0.000446416,0.005071497,0.00008182358],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907774,0.001754904,0.0005835562,0.0001884768,0.00004445539,0.0002399027,0.005208862,0.00002455561,0.001177906],"genre_scores_gemma":[0.9944485,0.0001473432,0.0003486384,0.0001540597,0.00006019033,0.000222829,0.004031797,0.00000694818,0.0005795451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005789343,"threshold_uncertainty_score":0.0306173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01253221888091933,"score_gpt":0.286206911600602,"score_spread":0.2736746927196827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}