{"id":"W3214003785","doi":"10.1007/s00280-021-04369-0","title":"A phase 1b study of erlotinib and momelotinib for the treatment of EGFR-mutated, tyrosine kinase inhibitor-naive metastatic non-small cell lung cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sierra Wireless (Canada)","funders":"Gilead Sciences","keywords":"Erlotinib; Medicine; Tyrosine-kinase inhibitor; Internal medicine; Lung cancer; Pharmacology; Clinical endpoint; Oncology; Epidermal growth factor receptor; Cancer; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001987705,0.001528555,0.001869145,0.0004905091,0.0004963093,0.0008906581,0.001065867,0.001530554,0.00423531],"category_scores_gemma":[0.00083327,0.0007802359,0.001195721,0.0004308075,0.0008098234,0.0009174861,0.0003443256,0.003172959,0.0009818316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009378863,"about_ca_system_score_gemma":0.001950543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009469814,"about_ca_topic_score_gemma":0.003059963,"domain_scores_codex":[0.9995173,0.0002181575,0.00002945154,0.00008088395,0.00005755003,0.000096626],"domain_scores_gemma":[0.9993937,0.00008560355,0.0001171436,0.0000429176,0.00004373866,0.0003169802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.699963,0.1384372,0.006589863,0.001101298,0.001517205,0.0004050542,0.0003651156,0.00250132,0.06864578,0.0003554998,0.00396105,0.07615757],"study_design_scores_gemma":[0.608294,0.3768215,0.007726007,0.00002869392,0.0003089124,0.000230509,0.00004023638,0.0008182437,0.003577491,0.0001329026,0.001996255,0.00002535818],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911214,0.001903257,0.0005367402,0.0004631983,0.00009876848,0.003343615,0.0008919967,0.0000717372,0.001569316],"genre_scores_gemma":[0.9852938,0.002080936,0.001860358,0.0008972634,0.0001512053,0.004033015,0.002389484,0.00002970904,0.003264313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00423531,"threshold_uncertainty_score":0.0141685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02987213903771854,"score_gpt":0.3992001376410065,"score_spread":0.369327998603288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}