{"id":"W3214021630","doi":"10.1371/journal.ppat.1010034","title":"Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; University of Toronto; University of Pennsylvania; National Institute of Allergy and Infectious Diseases; Philadelphia Foundation; Cancer Prevention and Research Institute of Texas; Welch Foundation; U.S. Department of Defense","keywords":"SIGLEC; Cytotoxic T cell; Biology; NK-92; Interleukin 12; Lymphokine-activated killer cell; Interleukin 21; Perforin; Immune system; Cytotoxicity; CD16; Immunology; Cell biology; CD8; In vitro; CD3; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006493181,0.0001904941,0.0001712092,0.0002483151,0.0001567236,0.0004160386,0.0001712324,0.0002110951,0.001033224],"category_scores_gemma":[0.0001194194,0.00008063224,0.0001646346,0.0001482985,0.0001397346,0.0001742841,0.0003292946,0.0002704792,0.0003862825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000169157,"about_ca_system_score_gemma":0.0001247084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002117993,"about_ca_topic_score_gemma":0.0002669203,"domain_scores_codex":[0.9998754,0.000013299,0.00001419348,0.00002737347,0.00002648049,0.00004318856],"domain_scores_gemma":[0.9999319,0.000009570719,0.00001573945,0.00001201391,0.00001181837,0.00001890385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008534581,0.00002248051,0.00174575,0.00002739051,0.000004107866,0.0001447662,0.00002528029,0.00004936893,0.994154,0.00009350154,0.00004292321,0.003605062],"study_design_scores_gemma":[0.00003491667,0.0007584842,0.09940169,0.00003523814,0.00006975283,0.004843071,0.0001942543,0.002498992,0.8832718,0.0003153542,0.008554454,0.0000220102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964761,0.0007385802,0.001184774,0.00002347754,0.00001198001,0.00002268375,0.0001167732,0.00004290173,0.001382661],"genre_scores_gemma":[0.9972264,0.0003045924,0.000904044,0.0000318512,0.00001643348,0.00001840334,0.0002461002,0.000007312145,0.001244897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001033224,"threshold_uncertainty_score":0.003456473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0131770231273071,"score_gpt":0.2190228022854858,"score_spread":0.2058457791581787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}