{"id":"W3214033886","doi":"10.1101/2021.11.09.467923","title":"Age-Dependent Formation of TMEM106B Amyloid Filaments in Human Brain","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Japan Society for the Promotion of Science; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology,University College London; National Center of Neurology and Psychiatry; National Institutes of Health; Rossy Foundation; School of Medicine, Indiana University; Biotechnology and Biological Sciences Research Council; Medical Research Council; European Federation of Pharmaceutical Industries and Associations; National Institute for Health and Care Research; Diamond Light Source; Wellcome Trust; Japan Agency for Medical Research and Development","keywords":"Amyloid (mycology); Transmembrane protein; Amyloid fibril; Chemistry; Synucleinopathies; Biology; Cell biology; Biophysics; Amyloid β; Pathology; Alpha-synuclein; Biochemistry; Disease; Medicine; Receptor; Parkinson's disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001967956,0.000231048,0.0001745889,0.0003772535,0.0001800318,0.0002080312,0.0001054383,0.0004047401,0.001207092],"category_scores_gemma":[0.0002222656,0.0001506228,0.0002357118,0.0001646382,0.0001373573,0.0001437014,0.0001969488,0.0003437965,0.0005200478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000118911,"about_ca_system_score_gemma":0.00005395827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005087088,"about_ca_topic_score_gemma":0.000255201,"domain_scores_codex":[0.9999336,0.00001024249,0.000007003221,0.00002127234,0.00001635619,0.00001150221],"domain_scores_gemma":[0.9998989,0.00001234719,0.00003479622,0.00001178851,0.00002303516,0.00001911349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003629563,0.00003073282,0.006414576,0.00006170748,0.00003172345,0.0006324139,0.0001548814,0.0001067538,0.9893997,0.00007866079,0.0002669464,0.002459009],"study_design_scores_gemma":[0.00006658521,0.0007410386,0.3670493,0.00005641305,0.0001012877,0.01888897,0.0003025013,0.001945638,0.6000182,0.0007027531,0.01010024,0.00002701364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957528,0.001621029,0.001150592,0.00008622387,0.00001732502,0.00001284845,0.0004014753,0.00003536768,0.0009222974],"genre_scores_gemma":[0.9948094,0.0007854581,0.001722931,0.00007683156,0.0000105824,0.00001797446,0.001541021,0.00001810404,0.001017744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001207092,"threshold_uncertainty_score":0.004038095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0264380513015391,"score_gpt":0.2853281039627643,"score_spread":0.2588900526612252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}