{"id":"W3214043801","doi":"10.1182/blood-2021-146572","title":"Single-Cell Proteogenomic Sequencing Allows Early Detection of Relapse Clone with CN-LOH at <i>FLT3</i>-ITD Locus from Initial Diagnosis in AML","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"NPM1; Oncology; Medicine; Internal medicine; Midostaurin; CDKN2A; Myeloid leukemia; Biology; Karyotype; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000982046,0.0001997842,0.0001796525,0.0006317219,0.0001631161,0.0003363847,0.0001139027,0.0002650028,0.0008345585],"category_scores_gemma":[0.0002810771,0.0000907547,0.0001510641,0.0002289472,0.0001265996,0.0001266357,0.000209976,0.0001829091,0.0002890856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001534226,"about_ca_system_score_gemma":0.00008757963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007247063,"about_ca_topic_score_gemma":0.00126945,"domain_scores_codex":[0.9998964,0.000007252735,0.000009117186,0.00004261121,0.00002467832,0.00001997128],"domain_scores_gemma":[0.9999049,0.00002310443,0.00002386802,0.00001057113,0.00001887425,0.00001882785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003330847,0.00004637091,0.101255,0.00006679105,0.00002015764,0.007185163,0.0002622965,0.000558603,0.8570958,0.0001444016,0.0005876085,0.03244465],"study_design_scores_gemma":[0.00002239569,0.0004296538,0.574161,0.00002959617,0.0001244018,0.04555895,0.0003638449,0.01065756,0.3594078,0.0004093015,0.008812041,0.00002341882],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995261,0.0003770769,0.002702017,0.00007490295,0.000008873294,0.00002668982,0.0007073537,0.00008659404,0.0007555741],"genre_scores_gemma":[0.9948014,0.0001609033,0.003634923,0.0000361012,0.000007361677,0.00001059665,0.0009119681,0.00001701628,0.0004198591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008345585,"threshold_uncertainty_score":0.002791882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02195712414073691,"score_gpt":0.2407634925257403,"score_spread":0.2188063683850034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}