{"id":"W3214066594","doi":"10.1101/2021.11.12.468344","title":"<i>Mycobacterium tuberculosis</i> senses host Interferon-γ via the membrane protein MmpL10","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; National Institutes of Health; University of Southampton; Wellcome Trust","keywords":"Mycobacterium tuberculosis; Microbiology; Virulence; Biology; Immune system; Interferon; Tuberculosis; Interferon gamma; Isoniazid; Virology; Complementation; Tuberculosis vaccines; Mycobacterium; Bacteria; Gene; Mutant; Immunology; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001306835,0.0003531527,0.0001843933,0.0001391512,0.0001197969,0.0003663263,0.0001720552,0.0002932962,0.001501515],"category_scores_gemma":[0.0001472567,0.0001056845,0.0002027438,0.00009847918,0.0001830706,0.0001678612,0.0001914905,0.0004627202,0.0009711879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003755628,"about_ca_system_score_gemma":0.00008476334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003784459,"about_ca_topic_score_gemma":0.000403967,"domain_scores_codex":[0.9998538,0.00002609971,0.00001097058,0.00002911672,0.00004529309,0.00003470431],"domain_scores_gemma":[0.9998884,0.00001860835,0.00004003417,0.00001339215,0.00001820539,0.00002132744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004532259,0.000004966577,0.0002162348,0.00001888124,9.206065e-7,0.00002898856,0.000005033054,0.00001337034,0.9993101,0.00002383982,0.00003734077,0.0002950285],"study_design_scores_gemma":[0.00001049533,0.0001746385,0.01016165,0.00001642945,0.000006636147,0.0005390228,0.00005285858,0.0009686379,0.9846433,0.00007451064,0.003346096,0.000005620628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886155,0.0024106,0.003950865,0.0004460981,0.00008007516,0.0000307246,0.001003359,0.0001821275,0.003280644],"genre_scores_gemma":[0.9940224,0.0005494202,0.001962144,0.0001321174,0.00002350195,0.00001825213,0.001012517,0.00002226912,0.002257486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001501515,"threshold_uncertainty_score":0.005023003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01803890756108953,"score_gpt":0.2568345956992228,"score_spread":0.2387956881381333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}