{"id":"W3214072263","doi":"10.1182/blood-2021-153660","title":"Enasidenib in Combination with Venetoclax in <i>IDH2</i>-Mutated Myeloid Malignancies: Preliminary Results of the Phase Ib/II Enaven-AML Trial","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Venetoclax; IDH2; Medicine; Internal medicine; Ven; Myeloid leukemia; Myeloid; Oncology; IDH1; Leukemia; Biology; Mutation; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000872834,0.0006075007,0.0009040983,0.000165259,0.0001959178,0.0007657657,0.0003976672,0.000512162,0.003243397],"category_scores_gemma":[0.0004036368,0.0001668789,0.0006505781,0.0002308672,0.000362713,0.0004864241,0.0002488066,0.002139418,0.0005532106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004424645,"about_ca_system_score_gemma":0.0006213229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004522809,"about_ca_topic_score_gemma":0.00187749,"domain_scores_codex":[0.9998391,0.00008225493,0.00001104371,0.0000228781,0.00001706179,0.000027605],"domain_scores_gemma":[0.9997373,0.00005101212,0.00003746877,0.00001757956,0.00001542714,0.000141241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6226678,0.02498225,0.00791853,0.002155476,0.002498769,0.0005487789,0.0003055545,0.004898376,0.06006357,0.001156234,0.01655603,0.2562486],"study_design_scores_gemma":[0.6657211,0.2719771,0.02066977,0.0002214962,0.001369902,0.001200762,0.0001168526,0.003435965,0.009805106,0.000860289,0.02457373,0.00004789552],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770513,0.00997337,0.0007721997,0.001038877,0.0002502666,0.001470839,0.002318853,0.0001745648,0.006949638],"genre_scores_gemma":[0.9844027,0.004312356,0.00152278,0.000964566,0.0002017135,0.001049515,0.003593782,0.00003190539,0.003920706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003243397,"threshold_uncertainty_score":0.01085019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01857005648884793,"score_gpt":0.2886640578184658,"score_spread":0.2700940013296179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}