{"id":"W3214077599","doi":"10.2967/jnumed.121.262562","title":"Glypican-3–Targeted <sup>227</sup>Th <b>α</b>-Therapy Reduces Tumor Burden in an Orthotopic Xenograft Murine Model of Hepatocellular Carcinoma","year":2021,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; TRIUMF","funders":"","keywords":"Glypican 3; Biodistribution; In vivo; Hepatocellular carcinoma; Cancer research; Medicine; Radioimmunotherapy; Cancer; Antibody; Chemistry; Monoclonal antibody; Immunology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004018261,0.0002085556,0.0007870314,0.000174762,0.00005083558,0.000008445121,0.0002010438,0.0001024407,0.0008317847],"category_scores_gemma":[0.0001893483,0.0001624902,0.0001577971,0.000477796,0.0002249985,0.0001163624,0.00003075076,0.0006448298,0.000003372601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007698268,"about_ca_system_score_gemma":0.0002632828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002083956,"about_ca_topic_score_gemma":7.069887e-7,"domain_scores_codex":[0.9978584,0.00007522947,0.0009922447,0.0002509608,0.0005471347,0.0002760379],"domain_scores_gemma":[0.9982956,0.00006480455,0.0003593341,0.0003725312,0.0004557203,0.0004519925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000746464,0.0006437213,0.01048285,0.0001757455,0.00009498446,0.001165113,0.001489573,0.0008890239,0.981796,0.00009683151,0.0007674257,0.001652275],"study_design_scores_gemma":[0.02871127,0.004068331,0.02943826,0.002002479,0.0008195066,0.005373377,0.007616325,0.3814588,0.5035127,0.0008233063,0.03542302,0.0007526989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887676,0.002023254,0.00002947443,0.008244435,0.00004065092,0.0001933345,0.000006147096,0.00001796385,0.0006771996],"genre_scores_gemma":[0.9955525,0.0005357615,0.001917399,0.0009715158,0.0007695068,0.000003759874,0.00001603432,0.00004068037,0.0001928347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4782833,"threshold_uncertainty_score":0.9107459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05099395880274507,"score_gpt":0.3161427775374047,"score_spread":0.2651488187346597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}