{"id":"W3214083702","doi":"10.1158/0008-5472.can-21-3360","title":"HER3 Is an Actionable Target in Advanced Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Cancer Institute; Wellcome Trust Centre for Mitochondrial Research; Daiichi Sankyo Company; Imperial Experimental Cancer Medicine Centre; Stand Up To Cancer; National Institute for Health and Care Research; Prostate Cancer UK; Mark Foundation For Cancer Research; National Institutes of Health; Prostate Cancer Foundation; Cancer Research UK; Academy of Medical Sciences; Wellcome Trust; Chordoma Foundation","keywords":"Prostate cancer; Prostate; Cancer; PCA3; ErbB; Antibody; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001402714,0.0002145026,0.0004420038,0.0004442083,0.0002246429,0.0001053705,0.0003228027,0.0001785758,0.01909231],"category_scores_gemma":[0.000341564,0.0002096541,0.00008198742,0.002444785,0.000277205,0.0003587316,0.000235961,0.001696504,0.0002080938],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002379015,"about_ca_system_score_gemma":0.006674197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005144034,"about_ca_topic_score_gemma":0.00389355,"domain_scores_codex":[0.994871,0.0004014349,0.0003767581,0.0009866032,0.001899514,0.001464746],"domain_scores_gemma":[0.9967391,0.0001336782,0.00004202784,0.0009060358,0.001575589,0.000603588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00295891,0.001084365,0.2759699,0.001910982,0.0001919268,0.00216361,0.005576663,0.0009224226,0.4405973,0.0003439199,0.1162668,0.1520132],"study_design_scores_gemma":[0.00379457,0.0004672678,0.03423371,0.0009882633,0.00001253871,0.00003780718,0.002375729,0.000540673,0.3859252,0.001251914,0.5699959,0.0003764109],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9560919,0.01233638,0.000007075186,0.02146327,0.0003978105,0.001249143,0.0001431451,0.0000741915,0.008237113],"genre_scores_gemma":[0.8896722,0.0148624,0.0009576235,0.001665864,0.0008890477,0.003664875,0.00008493955,0.0001620664,0.08804095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4537291,"threshold_uncertainty_score":0.998957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1537256624313842,"score_gpt":0.5247178831692222,"score_spread":0.3709922207378379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}