{"id":"W3214083702","doi":"10.1158/0008-5472.can-21-3360","title":"HER3 Is an Actionable Target in Advanced Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Cancer Institute; Wellcome Trust Centre for Mitochondrial Research; Daiichi Sankyo Company; Imperial Experimental Cancer Medicine Centre; Stand Up To Cancer; National Institute for Health and Care Research; Prostate Cancer UK; Mark Foundation For Cancer Research; National Institutes of Health; Prostate Cancer Foundation; Cancer Research UK; Academy of Medical Sciences; Wellcome Trust; Chordoma Foundation","keywords":"Prostate cancer; Prostate; Cancer; PCA3; ErbB; Antibody; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001449102,0.0002075595,0.0002089074,0.0001442782,0.0001291799,0.000207806,0.0001275982,0.0002033329,0.002020455],"category_scores_gemma":[0.0000614382,0.00005566483,0.0001686273,0.000199465,0.0001635027,0.00009840108,0.0001830019,0.0003771853,0.0004516074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004011239,"about_ca_system_score_gemma":0.0002545146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008734159,"about_ca_topic_score_gemma":0.001075901,"domain_scores_codex":[0.9999037,0.00001534224,0.000004157758,0.00001370446,0.00003234182,0.00003077592],"domain_scores_gemma":[0.999965,0.000004900818,0.000009273098,0.000003388229,0.000005475606,0.00001200268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003825322,0.00004648824,0.00124863,0.0001438355,0.00001281935,0.0002159103,0.00001569518,0.0002757582,0.9852268,0.0003740747,0.0004612526,0.01159632],"study_design_scores_gemma":[0.00008314075,0.001197244,0.02260908,0.00003069263,0.00006473693,0.00371326,0.00004621813,0.001432428,0.941126,0.0004748134,0.0292078,0.00001460155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9588391,0.0249627,0.00539983,0.0006932941,0.00008528756,0.00007408576,0.0009194891,0.0003770665,0.008649134],"genre_scores_gemma":[0.9941658,0.002629068,0.000945106,0.0001339734,0.00001708479,0.00001279711,0.0002755502,0.00001288861,0.00180767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002020455,"threshold_uncertainty_score":0.006759048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1537256624313842,"score_gpt":0.5247178831692222,"score_spread":0.3709922207378379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}