{"id":"W3214124297","doi":"10.1111/cmi.13400","title":"Vam6/Vps39/ <scp>TRAP1</scp> ‐domain proteins influence vacuolar morphology, iron acquisition and virulence in <i>Cryptococcus neoformans</i>","year":2021,"lang":"en","type":"article","venue":"Cellular Microbiology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Michael Smith Health Research BC; Kelowna General Hospital; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canadian Institute for Advanced Research; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Cryptococcus neoformans; Biology; Mutant; Virulence; Fungal protein; Virulence factor; Saccharomyces cerevisiae; Vacuolar protein sorting; Cell biology; Transcription factor; Biochemistry; Microbiology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000839612,0.0003089943,0.0001271511,0.00016337,0.0001407514,0.0002971899,0.000154322,0.0002603462,0.0006922626],"category_scores_gemma":[0.0001140224,0.0001248854,0.0001879952,0.0001003474,0.0002364327,0.00009045567,0.0001868946,0.0003733305,0.000182597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004150999,"about_ca_system_score_gemma":0.0001563851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002001946,"about_ca_topic_score_gemma":0.001983244,"domain_scores_codex":[0.9998835,0.00001588792,0.00001068905,0.00001773338,0.00003321133,0.00003888175],"domain_scores_gemma":[0.9998969,0.00001873638,0.00002627676,0.000007523631,0.000009188155,0.0000414251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005205308,0.00001276654,0.0001664868,0.000005959466,0.000001617838,0.00004131738,0.000005880383,0.00003156044,0.999435,0.00001827198,0.0000086561,0.0002204399],"study_design_scores_gemma":[0.000009153798,0.0001652593,0.01219434,0.000004025484,0.00001153312,0.0004532494,0.00004444543,0.00113052,0.9850445,0.00003361175,0.0009044733,0.00000490399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991686,0.0001308471,0.0001773417,0.00002407146,0.00000330382,0.000004402404,0.0001142372,0.00001486551,0.0003623483],"genre_scores_gemma":[0.9986162,0.00008095025,0.000329408,0.00001934401,0.000001394707,0.000004508304,0.0001538733,0.00001355698,0.0007807497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002001946,"threshold_uncertainty_score":0.003980577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006058731337949184,"score_gpt":0.2176428813626624,"score_spread":0.2115841500247132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}