{"id":"W3214124297","doi":"10.1111/cmi.13400","title":"Vam6/Vps39/ <scp>TRAP1</scp> ‐domain proteins influence vacuolar morphology, iron acquisition and virulence in <i>Cryptococcus neoformans</i>","year":2021,"lang":"en","type":"article","venue":"Cellular Microbiology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Michael Smith Health Research BC; Kelowna General Hospital; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canadian Institute for Advanced Research; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Cryptococcus neoformans; Biology; Mutant; Virulence; Fungal protein; Virulence factor; Saccharomyces cerevisiae; Vacuolar protein sorting; Cell biology; Transcription factor; Biochemistry; Microbiology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002847043,0.0002484231,0.0004616649,0.0001578238,0.0001770999,0.00001880658,0.00008401486,0.0003138666,0.00005787901],"category_scores_gemma":[0.0001146656,0.0002300517,0.00008418762,0.0003275196,0.0003654801,0.0001042127,0.0001681964,0.0004277249,0.00009186878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000853426,"about_ca_system_score_gemma":0.00008848833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006019729,"about_ca_topic_score_gemma":0.00005430548,"domain_scores_codex":[0.9984167,0.0001665006,0.0003429301,0.0005192651,0.00004824311,0.0005063369],"domain_scores_gemma":[0.9992439,0.0001118246,0.00009327402,0.0003244797,0.0001324927,0.00009407179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002116908,0.0001627594,0.02714772,0.0001256271,0.0000364531,0.0004287378,0.0004340933,0.00002049493,0.9704807,0.0002542667,0.0007131698,0.0001747938],"study_design_scores_gemma":[0.003137136,0.0009166205,0.06247321,0.0002521396,0.0001048284,0.002416084,0.0009312171,0.00003044417,0.8584762,0.0006266727,0.07038327,0.0002521354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916645,0.005496418,0.000720418,0.0004981442,0.000196681,0.0006186368,0.00004107143,0.00005654621,0.0007075391],"genre_scores_gemma":[0.9954058,0.0007485132,0.001581258,0.001308027,0.00008843237,0.0001128793,0.0001724122,0.00002334527,0.0005593561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1120045,"threshold_uncertainty_score":0.9381234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006058731337949184,"score_gpt":0.2176428813626624,"score_spread":0.2115841500247132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}