{"id":"W3214164674","doi":"10.1182/blood-2021-151208","title":"PIK-001 a Novel Small Molecule Inhibitor of Pikfyve for Treatment of Multiple Myeloma (MM)","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Ex vivo; In vivo; Pharmacology; Viability assay; Multiple myeloma; Cell culture; Biology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001209456,0.0002665452,0.0003299806,0.0002124854,0.00011153,0.000300119,0.0002578665,0.0002444688,0.001894568],"category_scores_gemma":[0.00007604618,0.0001151095,0.0002822288,0.0001715071,0.0001165587,0.0001488646,0.0001428733,0.0005169777,0.0004719203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002841709,"about_ca_system_score_gemma":0.0002407544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007147616,"about_ca_topic_score_gemma":0.002338245,"domain_scores_codex":[0.9999409,0.000007358934,0.000005537995,0.00001135374,0.00001572986,0.00001922449],"domain_scores_gemma":[0.9999804,0.000003658211,0.000003467901,0.000001883402,0.000003017013,0.000007601845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008060157,0.000408173,0.001399135,0.0001897948,0.00005911403,0.0002822707,0.0000325368,0.0005827049,0.9389256,0.0002482308,0.001108592,0.05595789],"study_design_scores_gemma":[0.001233385,0.01483463,0.03070777,0.00002895908,0.0002300032,0.003256566,0.00005154436,0.004623028,0.9174926,0.0001719153,0.02733283,0.00003672933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821686,0.006107782,0.003660509,0.0003835621,0.00007390958,0.00028449,0.0009679114,0.0002988564,0.006054382],"genre_scores_gemma":[0.9875728,0.002791491,0.00392565,0.0002510854,0.00002256937,0.0001160075,0.001524333,0.00001596574,0.003780087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001894568,"threshold_uncertainty_score":0.006337941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05673721515622571,"score_gpt":0.2632742377658461,"score_spread":0.2065370226096204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}