{"id":"W3214165942","doi":"10.1182/blood-2021-147805","title":"AGILE: A Global, Randomized, Double-Blind, Phase 3 Study of Ivosidenib + Azacitidine Versus Placebo + Azacitidine in Patients with Newly Diagnosed Acute Myeloid Leukemia with an <i>IDH1</i> Mutation","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; IDH1; Interquartile range; Clinical endpoint; Myeloid leukemia; Placebo; Gastroenterology; Phases of clinical research; Randomized controlled trial; Oncology; Surgery; Clinical trial; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002080145,0.002478303,0.003800587,0.0006207819,0.0005238985,0.001264345,0.001221464,0.001837712,0.009286552],"category_scores_gemma":[0.001345917,0.0009075264,0.002015089,0.0005903963,0.001812155,0.001167805,0.0006406769,0.003877829,0.001504155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005734078,"about_ca_system_score_gemma":0.001710326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000722459,"about_ca_topic_score_gemma":0.002019634,"domain_scores_codex":[0.9993575,0.0003681477,0.00002795371,0.0001164831,0.00004208934,0.00008778398],"domain_scores_gemma":[0.9991425,0.0001998579,0.0001857364,0.00006387538,0.0000564065,0.0003515838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9745561,0.00826757,0.0005245793,0.0005394604,0.0006570707,0.00003048963,0.00004773392,0.0002712708,0.003376981,0.0001022711,0.0009876818,0.0106387],"study_design_scores_gemma":[0.9568375,0.04149291,0.000703312,0.00001745606,0.000170983,0.00001589506,0.00001116722,0.0001254099,0.0001779073,0.00008565304,0.0003546829,0.000007158071],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969396,0.005786661,0.0017042,0.001195898,0.0009500365,0.0133935,0.003125602,0.000486546,0.003961677],"genre_scores_gemma":[0.9621754,0.00416461,0.004652372,0.002874993,0.0007018259,0.01813885,0.002623086,0.00009455613,0.004574246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009286552,"threshold_uncertainty_score":0.0310666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02116765653613802,"score_gpt":0.309553975274763,"score_spread":0.288386318738625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}