{"id":"W3214168639","doi":"10.1021/acs.analchem.1c03617","title":"Split Locations and Secondary Structures of a DNAzyme Critical to Binding-Assembled Multicomponent Nucleic Acid Enzymes for Protein Detection","year":2021,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Health; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Deoxyribozyme; Nucleic acid; Chemistry; RNA; Cleavage (geology); Protein secondary structure; DNA; Thymine; Catalysis; Nucleic acid structure; Biochemistry; Nucleic acid secondary structure; Enzyme; Combinatorial chemistry; Biophysics; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002020921,0.0002542987,0.0001709393,0.0001403445,0.0001800216,0.0003390491,0.0001965371,0.0003927282,0.001818768],"category_scores_gemma":[0.0005709768,0.0002613221,0.0001921113,0.0001085212,0.0003032173,0.0003331047,0.0001789634,0.0007038369,0.0006925011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001959441,"about_ca_system_score_gemma":0.0002111702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001374435,"about_ca_topic_score_gemma":0.0004894685,"domain_scores_codex":[0.9999181,0.00001372066,0.000006557887,0.0000263747,0.00002578874,0.000009444195],"domain_scores_gemma":[0.9993039,0.000196535,0.0001889821,0.00006580016,0.00008470674,0.000160096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004845677,0.00001274947,0.0001908026,0.0000205435,0.000003087892,0.00002483607,0.00001747688,0.00009952664,0.9984571,0.0002243967,0.00001524709,0.0008857576],"study_design_scores_gemma":[0.00001013578,0.0001673436,0.001860797,0.000003550173,0.000009507997,0.0002224724,0.00001661274,0.001178215,0.9956038,0.0002412254,0.0006824319,0.000004039915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753171,0.0004237485,0.02281291,0.00008657177,0.00002979458,0.00003295471,0.0001288703,0.0001279731,0.0010401],"genre_scores_gemma":[0.9816343,0.0001249661,0.01673527,0.00006460353,0.000008771222,0.00002883339,0.0002904913,0.0000333296,0.00107951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001818768,"threshold_uncertainty_score":0.006084383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01063553553447807,"score_gpt":0.2919393265759427,"score_spread":0.2813037910414647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}