{"id":"W3214187946","doi":"10.1093/ecco-jcc/jjab194","title":"Clinical, Endoscopic, and Safety Placebo Rates in Induction and Maintenance Trials of Crohn’s Disease: Meta-Analysis of Randomised Controlled Trials","year":2021,"lang":"en","type":"review","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; University of Calgary; Robarts Clinical Trials; Western University","funders":"UCB Pharma; Allergan; Genentech; Akebia Therapeutics; Universiteit van Amsterdam; BeiGene; Mylan; AbbVie; Teva Pharmaceutical Industries; Gilead Sciences; Sanofi; Celgene; Biogen; GlaxoSmithKline; Tillotts Pharma; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Placebo; Medicine; Internal medicine; Meta-analysis; Clinical trial; Confidence interval; Clinical endpoint; Randomized controlled trial; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1218062,0.00505633,0.02871407,0.01039585,0.0006902082,0.007284287,0.00391617,0.004317083,0.002374877],"category_scores_gemma":[0.2191889,0.002725472,0.06560561,0.009267317,0.001919828,0.004365654,0.00270149,0.004068592,0.0002833099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003569179,"about_ca_system_score_gemma":0.002678989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002393749,"about_ca_topic_score_gemma":0.002835574,"domain_scores_codex":[0.8169548,0.1334252,0.03095019,0.007902527,0.009770751,0.0009964848],"domain_scores_gemma":[0.7988316,0.1657449,0.02364716,0.006659469,0.004324585,0.0007922669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00820555,0.00002645521,0.003856987,0.08306121,0.8957555,0.00005585765,0.00005959061,0.0009872235,0.0001127202,0.0002197735,0.0003394977,0.00731968],"study_design_scores_gemma":[0.00395021,0.0003784473,0.003130155,0.008692115,0.9811761,0.00007950011,0.00003076934,0.0006714473,0.0001427971,0.0009381953,0.0007768683,0.00003353644],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007883157,0.9846743,0.004528813,0.0004821927,0.0005280694,0.0008953696,0.0004753311,0.00008044582,0.0004523505],"genre_scores_gemma":[0.5142701,0.447463,0.0228722,0.002276084,0.001436911,0.008724902,0.002057256,0.0002136402,0.0006859349],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1218062,"threshold_uncertainty_score":0.6441802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09053195308161957,"score_gpt":0.3969962255119109,"score_spread":0.3064642724302913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}