{"id":"W3214232282","doi":"10.1136/jitc-2021-sitc2021.353","title":"353 Identification of potential response predictors to maveropepimut-S (DPX-Survivac), a novel T cell activating immunotherapy, in patients with advanced recurrent ovarian cancer","year":2021,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Immunotherapy; CD8; Immune system; T cell; Antigen; Ovarian cancer; Oncology; Immunohistochemistry; Cancer research; Cancer; Cyclophosphamide; Internal medicine; Chemotherapy; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006466656,0.0003154074,0.0004585847,0.0002214636,0.0001826967,0.00004790386,0.0002176704,0.0002408558,0.00005404526],"category_scores_gemma":[0.0003596908,0.0002898613,0.00008526142,0.0004022197,0.0002309597,0.0002752118,0.00007777534,0.0003391329,0.000009367935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001123302,"about_ca_system_score_gemma":0.0004897267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001851557,"about_ca_topic_score_gemma":0.00002406998,"domain_scores_codex":[0.9976762,0.0004318014,0.0007746759,0.0005224865,0.0001609288,0.0004339092],"domain_scores_gemma":[0.9986169,0.0001202558,0.0004275461,0.0004854989,0.0002642819,0.0000854934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007805084,0.000436645,0.01924133,0.00005250432,0.0001796429,0.00000712556,0.001446822,0.0003138979,0.9663523,0.0000262431,0.00005191809,0.004086527],"study_design_scores_gemma":[0.003143394,0.0002753419,0.5042745,0.0002001598,0.00002088719,0.00001204498,0.0001964344,0.000003121664,0.4896416,0.000007240773,0.002012001,0.0002132257],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956045,0.002448644,0.0001629173,0.0003228643,0.000761165,0.0005045776,0.0001320163,0.00003765391,0.00002567587],"genre_scores_gemma":[0.9983721,0.0002174253,0.0003912189,0.0001200058,0.0000163538,0.0000536991,0.0001121884,0.00004833276,0.0006686443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4850332,"threshold_uncertainty_score":0.9999554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00683929153160976,"score_gpt":0.2201043896604499,"score_spread":0.2132650981288401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}