{"id":"W3214232282","doi":"10.1136/jitc-2021-sitc2021.353","title":"353 Identification of potential response predictors to maveropepimut-S (DPX-Survivac), a novel T cell activating immunotherapy, in patients with advanced recurrent ovarian cancer","year":2021,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Immunotherapy; CD8; Immune system; T cell; Antigen; Ovarian cancer; Oncology; Immunohistochemistry; Cancer research; Cancer; Cyclophosphamide; Internal medicine; Chemotherapy; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000189653,0.000134399,0.0002616163,0.0002820118,0.000126203,0.0002489801,0.00009349147,0.0002412912,0.0006893559],"category_scores_gemma":[0.0003249736,0.00007250303,0.0001727182,0.0002332059,0.0001078242,0.0001139463,0.0000955054,0.0002207978,0.0001469614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000159348,"about_ca_system_score_gemma":0.0001466851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006704924,"about_ca_topic_score_gemma":0.0008209003,"domain_scores_codex":[0.9999329,0.000014763,0.000005842384,0.00001797255,0.00001128591,0.00001719199],"domain_scores_gemma":[0.9998726,0.00003172814,0.000035485,0.000007611798,0.00001704774,0.00003556878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005011799,0.0003289449,0.9312537,0.00006012446,0.00007147744,0.0004476868,0.0001601691,0.0004019708,0.03559855,0.0000338116,0.0005267073,0.02610499],"study_design_scores_gemma":[0.0001146148,0.003673553,0.9863667,0.000008738219,0.00009262539,0.0009190467,0.0001353743,0.002103631,0.004958237,0.00006838488,0.001550871,0.000008350202],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992989,0.0002713256,0.00006804877,0.00001869504,0.000003285539,0.00001341852,0.0001067475,0.000004650467,0.000214857],"genre_scores_gemma":[0.9994734,0.00006462173,0.00009579317,0.00002356543,0.0000074454,0.00001263095,0.0002044892,0.000001116534,0.0001170364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006893559,"threshold_uncertainty_score":0.002306104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00683929153160976,"score_gpt":0.2201043896604499,"score_spread":0.2132650981288401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}