{"id":"W3214248259","doi":"10.1182/blood-2021-145995","title":"Post Hoc Analysis of Responses to Ponatinib in Patients with Chronic-Phase Chronic Myeloid Leukemia (CP-CML) By Baseline <i>BCR-ABL1</i> Level and Baseline Mutation Status in the Optic Trial","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ponatinib; Medicine; Myeloid leukemia; Internal medicine; Imatinib; Oncology; Dasatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006435659,0.001099261,0.002427594,0.0003402339,0.0002499505,0.0008700569,0.001003062,0.000880968,0.006054213],"category_scores_gemma":[0.006251897,0.0002993565,0.003758734,0.0003652463,0.0008025025,0.001111774,0.00080505,0.00206707,0.0005576592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009009315,"about_ca_system_score_gemma":0.001120065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000587599,"about_ca_topic_score_gemma":0.0009742902,"domain_scores_codex":[0.9949912,0.003259751,0.000218609,0.0006765084,0.0003406009,0.0005132985],"domain_scores_gemma":[0.9944569,0.003256746,0.0008598549,0.0005474629,0.0002680967,0.0006109973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.966678,0.001708908,0.0132984,0.0002916857,0.004579247,0.0000632736,0.00008003302,0.001326207,0.002644081,0.0001393025,0.001595902,0.00759486],"study_design_scores_gemma":[0.2564852,0.5027329,0.1921307,0.00009679678,0.01467518,0.0003466604,0.000373051,0.0154987,0.008404254,0.0009768943,0.008112679,0.0001670159],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954633,0.000465945,0.0005081304,0.0001363623,0.0001092758,0.0006098259,0.001277702,0.00004138207,0.001388053],"genre_scores_gemma":[0.9942747,0.0001312612,0.0006705202,0.0002390977,0.0001136896,0.001007412,0.001765591,0.00002545824,0.001772333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006435659,"threshold_uncertainty_score":0.03403544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01470383091207388,"score_gpt":0.2804255015344094,"score_spread":0.2657216706223355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}