{"id":"W3214268594","doi":"10.1096/fba.2021-00073","title":"Critical cysteines in the functional interaction of adenylyl cyclase isoform 6 with Gαs","year":2021,"lang":"en","type":"article","venue":"FASEB BioAdvances","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Heart and Stroke Foundation of Canada; Research Manitoba","keywords":"Adenylyl cyclase; Cysteine; Gene isoform; Protein subunit; Mutagenesis; Biochemistry; ADCY6; Intracellular; Cell biology; Chemistry; Gs alpha subunit; Biology; Signal transduction; Enzyme; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009150564,0.00007807892,0.00008521856,0.00002195269,0.00004147319,0.00001779262,0.00006705764,0.00004797179,0.0001068141],"category_scores_gemma":[0.0001232247,0.0000504601,0.00004140402,0.00009563195,0.00006140655,0.0000108484,0.00002221305,0.00005553482,0.0000019652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005037327,"about_ca_system_score_gemma":0.00005271762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007793758,"about_ca_topic_score_gemma":0.0001177207,"domain_scores_codex":[0.9994134,0.00004220991,0.0001368069,0.0001749122,0.0001221594,0.0001104772],"domain_scores_gemma":[0.9996678,0.00003904301,0.00003847066,0.0001318805,0.00009730405,0.00002550794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001369414,0.0000850186,0.001398686,0.00002767465,0.00001784383,0.00001704144,0.00005149404,0.0001881077,0.9947045,0.001276761,0.000196833,0.001899063],"study_design_scores_gemma":[0.0002858663,0.0002838187,0.0006462936,0.00004551143,0.00001136431,0.00008201631,0.00188169,0.00006242144,0.9846196,0.000225815,0.01176196,0.00009368574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992086,0.001254187,0.005109832,0.0004162782,0.0002429834,0.00005980377,0.00001628318,0.000003942095,0.0008106708],"genre_scores_gemma":[0.9982288,0.0001041225,0.001058859,0.0002138464,0.0001607801,0.00001458841,0.0000793344,0.000005879245,0.000133741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01156513,"threshold_uncertainty_score":0.2057703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01356551815189923,"score_gpt":0.2670567570438715,"score_spread":0.2534912388919723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}