{"id":"W3214268594","doi":"10.1096/fba.2021-00073","title":"Critical cysteines in the functional interaction of adenylyl cyclase isoform 6 with Gαs","year":2021,"lang":"en","type":"article","venue":"FASEB BioAdvances","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Heart and Stroke Foundation of Canada; Research Manitoba","keywords":"Adenylyl cyclase; Cysteine; Gene isoform; Protein subunit; Mutagenesis; Biochemistry; ADCY6; Intracellular; Cell biology; Chemistry; Gs alpha subunit; Biology; Signal transduction; Enzyme; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001596608,0.0004060518,0.0002670175,0.0001139284,0.0002550434,0.0002932945,0.0003837976,0.0004461884,0.001042913],"category_scores_gemma":[0.0002851028,0.0001517283,0.0003406217,0.0001176954,0.0003144062,0.0002285958,0.0002368551,0.0002981105,0.0002522856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004946367,"about_ca_system_score_gemma":0.0004279301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001570272,"about_ca_topic_score_gemma":0.001383809,"domain_scores_codex":[0.9999055,0.00001956169,0.000005141034,0.00002144323,0.00002644936,0.00002197347],"domain_scores_gemma":[0.9999201,0.0000213026,0.00002325556,0.000004547627,0.00001040176,0.00002037059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001341328,0.0001846459,0.008215304,0.0002280651,0.00007252383,0.001915366,0.0001688331,0.02523993,0.9486175,0.004498643,0.0003423058,0.009175682],"study_design_scores_gemma":[0.0003503273,0.0009748993,0.01906759,0.00004365671,0.0002287581,0.001612439,0.0002713797,0.08880727,0.8799192,0.003003762,0.005650315,0.00007046323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955934,0.0003703751,0.003161952,0.00007979631,0.0000133359,0.00001266991,0.0000533947,0.00003984927,0.0006752053],"genre_scores_gemma":[0.9981124,0.0001371138,0.001336735,0.00002235192,0.000002847039,0.000005841411,0.00007712364,0.000006196105,0.0002994047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001570272,"threshold_uncertainty_score":0.003588915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01356551815189923,"score_gpt":0.2670567570438715,"score_spread":0.2534912388919723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}