{"id":"W3214275655","doi":"10.1093/glycob/cwab094","title":"Crystal structure of the <i>Propionibacterium acnes</i> surface sialidase, a drug target for <i>P. acnes</i>-associated diseases","year":2021,"lang":"en","type":"article","venue":"Glycobiology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Propionibacterium acnes; Sialidase; Glycan; Microbiology; Pathogen; Acne; Antibiotics; Virulence; Chemistry; Human pathogen; Biology; Gene; Enzyme; Biochemistry; Glycoprotein; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002947471,0.0006387578,0.0005340554,0.0002318875,0.000630099,0.0009713679,0.001022572,0.000845183,0.003320699],"category_scores_gemma":[0.0006731924,0.0002996232,0.0002639299,0.0005800253,0.0002746905,0.0005329197,0.0002811449,0.002159396,0.0004449293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001136628,"about_ca_system_score_gemma":0.001388176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01246046,"about_ca_topic_score_gemma":0.008507637,"domain_scores_codex":[0.9997506,0.00003492932,0.00001110818,0.00004382122,0.0001106696,0.00004884094],"domain_scores_gemma":[0.9997026,0.00007796925,0.00004878409,0.00001227611,0.00008772449,0.00007062204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002693926,0.001469339,0.02407679,0.001547926,0.0005652498,0.002977815,0.001479534,0.04332869,0.8100619,0.01041875,0.05628448,0.0450956],"study_design_scores_gemma":[0.001633351,0.002128007,0.1073307,0.0004209024,0.0005807597,0.003814165,0.003072991,0.3650435,0.3289191,0.004925756,0.1816886,0.0004421635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9644665,0.007229049,0.005494046,0.002107661,0.000341695,0.00007964428,0.007617154,0.0004079235,0.01225634],"genre_scores_gemma":[0.9503258,0.005319215,0.01066225,0.0005532179,0.0000543057,0.000101045,0.02584408,0.0001620464,0.006977906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01246046,"threshold_uncertainty_score":0.02477586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006030769880486333,"score_gpt":0.2395579154053587,"score_spread":0.2335271455248723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}