{"id":"W3214276611","doi":"10.1101/2021.11.16.468891","title":"Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in non-alcoholic steatohepatitis and reversed by alternate day fasting","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Dietary Effects on Health","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Medical Research Council; Medical Research Council; Duke-NUS Medical School","keywords":"Steatohepatitis; Translation (biology); Lysosome; Internal medicine; Medicine; Endocrinology; Cell biology; Chemistry; Biology; Fatty liver; Biochemistry; Disease; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001167545,0.000649485,0.001443736,0.0005528863,0.00007224996,0.00009236521,0.0002640244,0.0006653123,0.00004615014],"category_scores_gemma":[0.0005834397,0.0007222412,0.0001545896,0.0007786809,0.0001616641,0.0002654489,0.0001974589,0.001033785,0.000005473519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002758735,"about_ca_system_score_gemma":0.0006984542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195774,"about_ca_topic_score_gemma":0.00003862358,"domain_scores_codex":[0.9959415,0.0004029263,0.001146348,0.001213376,0.0006256835,0.000670188],"domain_scores_gemma":[0.9970723,0.0002733356,0.0006996226,0.001108561,0.0004338568,0.0004122936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001274361,0.0002757745,0.08014474,0.004442123,0.000206558,0.0002035338,0.0001167646,0.00005287115,0.9143512,0.000005530421,0.00004604449,0.00002742374],"study_design_scores_gemma":[0.003600726,0.0002740874,0.4703189,0.005836961,0.0002494541,1.40448e-7,0.000009977057,0.007660952,0.5112528,7.298432e-7,0.000125356,0.0006699534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929076,0.002204933,0.0002516454,0.0004858971,0.0004019834,0.003138587,0.0004144553,0.000181584,0.0000132431],"genre_scores_gemma":[0.9934998,0.0010386,0.004693727,0.0001529208,0.000143298,0.0002821354,0.00001765438,0.0001661855,0.000005722952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4030985,"threshold_uncertainty_score":0.9995229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316028239577995,"score_gpt":0.236500418722764,"score_spread":0.223340136326984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}