{"id":"W3214288468","doi":"10.1002/path.5835","title":"Integrative multi‐omic analysis reveals neurodevelopmental gene dysregulation in <scp><i>CIC</i></scp>‐knockout and <scp><i>IDH1</i></scp>‐mutant cells","year":2021,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"BC Cancer Foundation; University of British Columbia; Canada Research Chairs; Canada Foundation for Innovation; Genome British Columbia; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre; Genome Canada","keywords":"Biology; Mutant; Knockout mouse; IDH1; Gene knockout; Context (archaeology); Transcriptome; Gene; Wild type; Mutation; Cancer research; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009716208,0.0002933921,0.0009318588,0.000538885,0.0001041551,0.00003019342,0.0001458707,0.0001568254,0.0000196162],"category_scores_gemma":[0.0007003446,0.0001885794,0.0002470715,0.0008306262,0.0001527961,0.0001084112,0.0001144073,0.0004584266,0.00001491799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001696097,"about_ca_system_score_gemma":0.0001670253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001912426,"about_ca_topic_score_gemma":0.0001591554,"domain_scores_codex":[0.9974738,0.0006557009,0.0008651091,0.0003098978,0.0003181451,0.0003773351],"domain_scores_gemma":[0.9974797,0.001087057,0.0006208869,0.0003114756,0.0003159607,0.0001849692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004323103,0.0007064859,0.1235731,0.00002285919,0.0008767686,0.006815973,0.007337577,0.0004269319,0.8578181,0.00003044899,0.0008223338,0.001526234],"study_design_scores_gemma":[0.003550338,0.0004369731,0.6435665,0.0001030195,0.001936903,0.006367788,0.004221343,0.0004606826,0.3387714,0.000195483,0.0003368027,0.000052763],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949936,0.003108421,0.0004847794,0.0007154825,0.0002581201,0.0002549512,0.0000275101,0.00001067745,0.0001464724],"genre_scores_gemma":[0.9932547,0.002170613,0.003408786,0.0007541351,0.00009325147,0.000009184638,0.00002655514,0.00002658787,0.0002562444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5199934,"threshold_uncertainty_score":0.7690045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488107160163868,"score_gpt":0.2648797865205011,"score_spread":0.2499987149188625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}