{"id":"W3214288468","doi":"10.1002/path.5835","title":"Integrative multi‐omic analysis reveals neurodevelopmental gene dysregulation in <scp><i>CIC</i></scp>‐knockout and <scp><i>IDH1</i></scp>‐mutant cells","year":2021,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"BC Cancer Foundation; University of British Columbia; Canada Research Chairs; Canada Foundation for Innovation; Genome British Columbia; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre; Genome Canada","keywords":"Biology; Mutant; Knockout mouse; IDH1; Gene knockout; Context (archaeology); Transcriptome; Gene; Wild type; Mutation; Cancer research; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001817337,0.0003323925,0.000521336,0.001025919,0.0003164957,0.0004560635,0.0002479656,0.0003035184,0.001386578],"category_scores_gemma":[0.0001264916,0.0001635295,0.0005618554,0.0008765399,0.0002452006,0.0001411806,0.000504141,0.0005143128,0.0004493274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002690863,"about_ca_system_score_gemma":0.0003375365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001305377,"about_ca_topic_score_gemma":0.00281865,"domain_scores_codex":[0.9997515,0.0000104395,0.00001318199,0.00008895645,0.00008542246,0.00005040516],"domain_scores_gemma":[0.9998468,0.00002976722,0.00005771298,0.00002071336,0.00001750507,0.00002748328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001194691,0.00001334939,0.003538912,0.0001073142,0.00004439426,0.0001496521,0.00004939251,0.0001666115,0.9926047,0.00009538022,0.0001643455,0.002946394],"study_design_scores_gemma":[0.00003226708,0.0003234109,0.4869564,0.00004747886,0.0003275573,0.001506676,0.000398431,0.006549219,0.4853606,0.000478924,0.01797061,0.00004840011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9634714,0.002273335,0.00829416,0.0001303402,0.00004236971,0.00005408688,0.02317734,0.0004644786,0.002092494],"genre_scores_gemma":[0.9428786,0.001790648,0.01471451,0.0003143246,0.00002558531,0.0001935098,0.03565756,0.0002700819,0.004155064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001386578,"threshold_uncertainty_score":0.004638553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488107160163868,"score_gpt":0.2648797865205011,"score_spread":0.2499987149188625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}